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Volume 31
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10.3390/curroncol31060235
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Review

Opioids and Cancer: Current Understanding and Clinical Considerations

by
Dhananjay Sah
1,2,
Hagit Shoffel-Havakuk
3,4,
Nir Tsur
3,4,
Megan L. Uhelski
5,
Vijaya Gottumukkala
1 and
Juan P. Cata
1,2,*
1
Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2
Anesthesiology and Surgical Oncology Research Group (ASORG), Houston, TX 77030, USA
3
Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petach Tiqva 4941492, Israel
4
Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
5
Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2024, 31(6), 3086-3098; https://doi.org/10.3390/curroncol31060235
Submission received: 3 May 2024 / Revised: 23 May 2024 / Accepted: 29 May 2024 / Published: 30 May 2024
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Abstract

Pain is one of the most common symptoms in patients with cancer. Pain not only negatively affects the quality of life of patients with cancer, but it has also been associated with reduced survival. Pain management is therefore a critical component of cancer care. Prescription opioids remain the first-line approach for the management of moderate-to-severe pain associated with cancer. However, there has been increasing interest in understanding whether these analgesics could impact cancer progression. Furthermore, epidemiological data link a possible association between prescription opioid usage and cancer development. Until more robust evidence is available, patients with cancer with moderate-to-severe pain may receive opioids to decrease suffering. However, future studies should be conducted to evaluate the role of opioids and opioid receptors in specific cancers.
Keywords: opioids; cancer biology; opioids and cancer biology; opioids and immune function; opioids; cancer opioids; cancer biology; opioids and cancer biology; opioids and immune function; opioids; cancer

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MDPI and ACS Style

Sah, D.; Shoffel-Havakuk, H.; Tsur, N.; Uhelski, M.L.; Gottumukkala, V.; Cata, J.P. Opioids and Cancer: Current Understanding and Clinical Considerations. Curr. Oncol. 2024, 31, 3086-3098. https://doi.org/10.3390/curroncol31060235

AMA Style

Sah D, Shoffel-Havakuk H, Tsur N, Uhelski ML, Gottumukkala V, Cata JP. Opioids and Cancer: Current Understanding and Clinical Considerations. Current Oncology. 2024; 31(6):3086-3098. https://doi.org/10.3390/curroncol31060235

Chicago/Turabian Style

Sah, Dhananjay, Hagit Shoffel-Havakuk, Nir Tsur, Megan L. Uhelski, Vijaya Gottumukkala, and Juan P. Cata. 2024. "Opioids and Cancer: Current Understanding and Clinical Considerations" Current Oncology 31, no. 6: 3086-3098. https://doi.org/10.3390/curroncol31060235

APA Style

Sah, D., Shoffel-Havakuk, H., Tsur, N., Uhelski, M. L., Gottumukkala, V., & Cata, J. P. (2024). Opioids and Cancer: Current Understanding and Clinical Considerations. Current Oncology, 31(6), 3086-3098. https://doi.org/10.3390/curroncol31060235

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