The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology
Abstract
:1. Introduction
2. The PI3K/Akt/mTOR Signaling Cascade
2.1. PI3K
2.2. Akt
2.3. mTOR
2.3.1. Functions and Regulation of mTORC1
2.3.2. Functions and Regulation of mTORC2
2.3.3. Feedback Loops Linking mTORC1/2 with Akt and MEK/ERK Signaling
3. Negative Regulation of PI3K/Akt/mTOR Signaling
4. PI3K/Akt/mTOR Signaling in Leukemic Stem Cells (LSCs)
5. PI3K/Akt/mTOR Signaling in CSCs
6. Therapeutic Targeting of PI3K/Akt/mTOR Signaling in LSCs and CSCs
7. Conclusions and Future Perspectives
Acknowledgments
References
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Martelli, A.M.; Evangelisti, C.; Chiarini, F.; Grimaldi, C.; McCubrey, J.A. The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology. Cancers 2010, 2, 1576-1596. https://doi.org/10.3390/cancers2031576
Martelli AM, Evangelisti C, Chiarini F, Grimaldi C, McCubrey JA. The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology. Cancers. 2010; 2(3):1576-1596. https://doi.org/10.3390/cancers2031576
Chicago/Turabian StyleMartelli, Alberto M., Camilla Evangelisti, Francesca Chiarini, Cecilia Grimaldi, and James A. McCubrey. 2010. "The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology" Cancers 2, no. 3: 1576-1596. https://doi.org/10.3390/cancers2031576