Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy
Abstract
:1. Introduction
2. Wound Healing Process
3. Current Therapies in Managing Wounds and the Potential of Mesoporous Materials
4. MSNs: Classification, Preparation Methods, and Biocompatibility
5. Multiple Roles of MSNs in Skin Wound Healing
5.1. Hemostatic Wound Care
5.2. Antibacterial and Antifungal Strategies
5.3. MSNs as Tissue Adhesives for Wound Closure
5.4. MSNs in Skin Cancer Therapy
6. Mesoporous Bioactive Glasses (MBGs)
7. MBGs for Wound Healing and Skin Regeneration
8. MBGs for Skin Cancer Therapy
8.1. MBGs for Hemostatic Applications
8.2. MBGs for Antibacterial Applications
8.3. MBGs for Angiogenesis
9. Conclusions and Future Challenges
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Composition | Synthesis Method | Dopant | Application | Remarks | Ref |
---|---|---|---|---|---|
1%Ga-MBG (79SiO2–15CaO–5P2O5–1Ga2O3) (10, 30, and 50 wt%) with CHT | Sol–gel using EISA with freeze-drying | Ga | Hemostatic and antibacterial |
| [139] |
(80 − x) SiO2 − 15CaO − 5P2O5 − xTa2O5, where x = 0, 0.5, 1, 5, 10 | Sol–gel using EISA | Ta | Hemostatic |
| [140] |
([1 − (x + y)] (58SiO2 − 33P2O5 − 9CaO) − xCaF2 − yAg2O), where 0 ≤ x ≤ 20, 0 ≤ y ≤ 2 | Sol–gel | Ag | Antibacterial |
| [141] |
MBGN (96.60SiO2-3.40CaO) and MBGN with Ag | Sol–gel using EA-CTAB-water micro-emulsion droplets | Ag | Antibacterial |
| [52] |
MBGSi80 (molar ratio Si/Ca/P = 80/15/5)&&&MBGSi78Cu2 (molar ratio Si/Cu/Ca/P = 78/2/15/5) and MBGSi75Cu5 (molar ratio Si/Cu/Ca/P = 75/5/15/5) | Sol–gel using EISA | Cu | Angiogenic and antibacterial |
| [138] |
85SiO2–13CaO–2CuO | Ultra-sound-assisted base catalyzed sol–gel method | Cu | Angiogenic and antibacterial |
| [40] |
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Hooshmand, S.; Mollazadeh, S.; Akrami, N.; Ghanad, M.; El-Fiqi, A.; Baino, F.; Nazarnezhad, S.; Kargozar, S. Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy. Materials 2021, 14, 3337. https://doi.org/10.3390/ma14123337
Hooshmand S, Mollazadeh S, Akrami N, Ghanad M, El-Fiqi A, Baino F, Nazarnezhad S, Kargozar S. Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy. Materials. 2021; 14(12):3337. https://doi.org/10.3390/ma14123337
Chicago/Turabian StyleHooshmand, Sara, Sahar Mollazadeh, Negar Akrami, Mehrnoosh Ghanad, Ahmed El-Fiqi, Francesco Baino, Simin Nazarnezhad, and Saeid Kargozar. 2021. "Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy" Materials 14, no. 12: 3337. https://doi.org/10.3390/ma14123337