Advanced Mass Spectrometric Techniques for the Comprehensive Study of Synthesized Silicon-Based Silyl Organic Compounds: Identifying Fragmentation Pathways and Characterization
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals and Reagents
2.2. Synthesis of 1-O-(Trimethylsilyl)-2,3,4,6-tetra-O-acetyl-β-d-glucopyranose (Compound 1)
2.3. Synthesis of 1-[(1,1-Dimethylehtyl)diphenylsilyl]-1H-indole (Compound 2)
2.4. Synthesis of O-Tert-butyldiphenylsilyl-(3-hydroxypropyl)oleate (Compound 3)
2.5. Synthesis of 1-O-Tert-Butyldiphenylsilyl-myo-inositol (Compound 4)
2.6. NMR Analysis
2.7. Compound Analysis Using Mass Spectrometry Techniques
2.7.1. NALDI/SALDI MS Analysis on Silver Nanoparticles
2.7.2. FT-ICR-MS Analysis
2.7.3. QqQ ESI-MS/MS Analysis
3. Results and Discussion
3.1. Characteristics of the Obtained Organic Compounds Using NMR Approach
3.2. Characteristics of the Obtained Organic Compounds Using Mass Spectrometry Techniques
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parent Ion | Theoretical m/z | NALDI-MS | ESI-FT-ICR MS | LC-QqQ-ESI-MS/MS |
---|---|---|---|---|
Experimental m/z | ||||
Compound 1: 1-O-(Trimethylsilyl)-2,3,4,6-tetra-O-acetyl-β-d-glucopyranose | ||||
[C17H28O10Si+H]+ | 421.15245 | - | - | - |
[C17H28O10Si+Na]+ | 443.13439 | 443.139 | 443.13439 | 443.10 |
[C17H28O10Si+K]+ | 459.10833 | 459.115 | - | - |
[C17H28O10Si+107Ag]+ | 527.04972 | 527.049 | - | - |
[C17H28O10Si+109Ag]+ | 529.04938 | 529.046 | - | - |
Compound 2: 1-[(1,1-dimethylehtyl)diphenylsilyl]-1H-indole | ||||
[C24H25NSi+H]+ | 356.18290 | - | 356.18291 | 356.10 |
[C24H25NSi+Na]+ | 378.16485 | 378.122 | - | - |
[C24H25NSi+107Ag]+ | 462.08017 | 462.085 | - | - |
[C24H25NSi+109Ag]+ | 464.07983 | 464.087 | - | - |
Compound 3: O-tert-butyldiphenylsilyl-(3-hydroxypropyl)oleate | ||||
[C37H58O3Si+H]+ | 579.42280 | - | 579.42276 | 579.20 |
[C37H58O3Si+Na]+ | 601.40474 | 601.405 | 601.40482 | - |
[C37H58O3Si+107Ag]+ | 685.32007 | 685.320 | - | - |
[C37H58O3Si+109Ag]+ | 687.31973 | 687.325 | - | - |
Compound 4: 1-O-tert-Butyldiphenylsilyl-myo-inositol | ||||
[C22H30O6Si+H]+ | 419.18844 | - | - | - |
[C22H30O6Si+Na]+ | 441.17039 | 441.175 | 441.17037 | 441.15 |
[C22H30O6Si+107Ag]+ | 525.08571 | 525.084 | - | - |
[C22H30O6Si+109Ag]+ | 527.08537 | 527.084 | - | - |
[C22H30O6Si-H]- | 417.17389 | - | - | 417.20 |
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Rogowska, A.; Szultka-Młyńska, M.; Kanawati, B.; Pomastowski, P.; Arendowski, A.; Gołębiowski, A.; Schmitt-Kopplin, P.; Fordymacka, M.; Sukiennik, J.; Krzywik, J.; et al. Advanced Mass Spectrometric Techniques for the Comprehensive Study of Synthesized Silicon-Based Silyl Organic Compounds: Identifying Fragmentation Pathways and Characterization. Materials 2023, 16, 3563. https://doi.org/10.3390/ma16093563
Rogowska A, Szultka-Młyńska M, Kanawati B, Pomastowski P, Arendowski A, Gołębiowski A, Schmitt-Kopplin P, Fordymacka M, Sukiennik J, Krzywik J, et al. Advanced Mass Spectrometric Techniques for the Comprehensive Study of Synthesized Silicon-Based Silyl Organic Compounds: Identifying Fragmentation Pathways and Characterization. Materials. 2023; 16(9):3563. https://doi.org/10.3390/ma16093563
Chicago/Turabian StyleRogowska, Agnieszka, Małgorzata Szultka-Młyńska, Basem Kanawati, Paweł Pomastowski, Adrian Arendowski, Adrian Gołębiowski, Phillipe Schmitt-Kopplin, Marta Fordymacka, Jarosław Sukiennik, Julia Krzywik, and et al. 2023. "Advanced Mass Spectrometric Techniques for the Comprehensive Study of Synthesized Silicon-Based Silyl Organic Compounds: Identifying Fragmentation Pathways and Characterization" Materials 16, no. 9: 3563. https://doi.org/10.3390/ma16093563