The Application of Regenerated Silk Fibroin in Tissue Repair
Abstract
:1. Introduction
1.1. Importance of Wound Repair
1.2. The Role of Soft Materials in Wound Repair
1.3. Current Soft Materials Used in Tissue Repair
1.4. Advantages of SF Soft Materials in Tissue Repair
2. Stages Involved in the Wound Repair Process
2.1. Hemostasis Phase
2.2. Inflammatory Phase
2.3. Proliferative Phase
2.4. Maturation Phase
3. Structure and Performance of SF Soft Materials
3.1. Structure of SF
3.2. Biological Properties of SF Materials
3.2.1. Immunogenicity
3.2.2. Cell Compatibility
3.2.3. Blood Compatibility
3.2.4. Biodegradability
3.2.5. In Vivo Implantation
3.2.6. Promoting Tissue Repair
4. Preparation of Regenerated SF Soft Materials
4.1. Preparation of SF Films
4.1.1. Control of Aggregate Structure
4.1.2. Chemical Crosslinking
4.1.3. Preparation of Composite Films
4.2. Hydrogels
4.2.1. Physical Crosslinking
4.2.2. Chemical Crosslinking
4.3. Porous Scaffolds
4.3.1. Freeze-Drying
4.3.2. Particle Leaching
4.3.3. Gas Foaming
4.3.4. Supercritical CO2 Processing
4.3.5. Three-Dimensional Bioprinting
4.3.6. Electrospinning Nonwoven Fabric
5. Applications of SF Soft Materials
5.1. Applications of SF Hydrogels
5.2. Applications of SF Porous Scaffolds
5.2.1. Skin Tissue Regeneration
5.2.2. Bone Tissue Regeneration
5.2.3. Cartilage Regeneration
5.2.4. Vascular Tissue Regeneration
5.2.5. Ligament and Tendon Regeneration
5.2.6. Nerve Tissue Regeneration
5.2.7. Regeneration of Other Tissues
6. Microenvironment Control in Wound Healing
6.1. Hemostasis Control in the First Phase of Wound Healing
6.2. Antibacterial Control in the Second Phase of Wound Healing
6.3. Promoting Cell Proliferation Control in the Third Phase of Wound Healing
6.4. Control of Tissue Remodeling in the Fourth Phase of Wound Healing
6.5. Composite Control across Different Stages
7. Summary and Outlook
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Li, Z.; Tan, G.; Xie, H.; Lu, S. The Application of Regenerated Silk Fibroin in Tissue Repair. Materials 2024, 17, 3924. https://doi.org/10.3390/ma17163924
Li Z, Tan G, Xie H, Lu S. The Application of Regenerated Silk Fibroin in Tissue Repair. Materials. 2024; 17(16):3924. https://doi.org/10.3390/ma17163924
Chicago/Turabian StyleLi, Zhaoyi, Guohongfang Tan, Huilin Xie, and Shenzhou Lu. 2024. "The Application of Regenerated Silk Fibroin in Tissue Repair" Materials 17, no. 16: 3924. https://doi.org/10.3390/ma17163924