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Pharmaceutics
Volume 10
Issue 4
10.3390/pharmaceutics10040213
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Article

Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs

by
Chiara Di Meo
1,†,
Mayte Martínez-Martínez
2,†,
Tommasina Coviello
1,
Marival Bermejo
2,
Virginia Merino
3,4,
Isabel Gonzalez-Alvarez
2,
Marta Gonzalez-Alvarez
2,* and
Pietro Matricardi
1
1
Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
2
Department of Pharmacokinetics and Pharmaceutical Technology, Miguel Hernandez University, San Juan de Alicante, 03550 Alicante, Spain
3
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, 46100 Burjassot, Spain
4
Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Universitat de València, 46100 Burjassot, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceutics 2018, 10(4), 213; https://doi.org/10.3390/pharmaceutics10040213
Submission received: 25 September 2018 / Revised: 27 October 2018 / Accepted: 30 October 2018 / Published: 3 November 2018
(This article belongs to the Special Issue Feature Papers for 10th Anniversary of Pharmaceutics)
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Abstract

Nanohydrogels based on natural polymers, such as polysaccharides, are gaining interest as vehicles for therapeutic agents, as they can modify the pharmacokinetics and pharmacodynamics of the carried drugs. In this work, hyaluronan-riboflavin nanohydrogels were tested in vivo in healthy rats highlighting their lack of toxicity, even at high doses, and their different biodistribution with respect to that of native hyaluronan. They were also exploited as carriers of a hydrophobic model drug, the anti-inflammatory piroxicam, that was physically embedded within the nanohydrogels by an autoclave treatment. The nanoformulation was tested by intravenous administration showing an improvement of the pharmacokinetic parameters of the molecule. The obtained results indicate that hyaluronan-based self-assembled nanohydrogels are suitable systems for low-soluble drug administration, by increasing the dose as well as the circulation time of poorly available therapeutic agents.
Keywords: nanohydrogels; hyaluronan; riboflavin; hydrophobic drugs; piroxicam; biodistribution; pharmacokinetic nanohydrogels; hyaluronan; riboflavin; hydrophobic drugs; piroxicam; biodistribution; pharmacokinetic
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MDPI and ACS Style

Di Meo, C.; Martínez-Martínez, M.; Coviello, T.; Bermejo, M.; Merino, V.; Gonzalez-Alvarez, I.; Gonzalez-Alvarez, M.; Matricardi, P. Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs. Pharmaceutics 2018, 10, 213. https://doi.org/10.3390/pharmaceutics10040213

AMA Style

Di Meo C, Martínez-Martínez M, Coviello T, Bermejo M, Merino V, Gonzalez-Alvarez I, Gonzalez-Alvarez M, Matricardi P. Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs. Pharmaceutics. 2018; 10(4):213. https://doi.org/10.3390/pharmaceutics10040213

Chicago/Turabian Style

Di Meo, Chiara, Mayte Martínez-Martínez, Tommasina Coviello, Marival Bermejo, Virginia Merino, Isabel Gonzalez-Alvarez, Marta Gonzalez-Alvarez, and Pietro Matricardi. 2018. "Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs" Pharmaceutics 10, no. 4: 213. https://doi.org/10.3390/pharmaceutics10040213

APA Style

Di Meo, C., Martínez-Martínez, M., Coviello, T., Bermejo, M., Merino, V., Gonzalez-Alvarez, I., Gonzalez-Alvarez, M., & Matricardi, P. (2018). Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs. Pharmaceutics, 10(4), 213. https://doi.org/10.3390/pharmaceutics10040213

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