Next Article in Journal
Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
Previous Article in Journal
Natural Deep Eutectic Solvents for Simultaneous Extraction of Multi-Bioactive Components from Jinqi Jiangtang Preparations
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceutics
Volume 11
Issue 1
10.3390/pharmaceutics11010019
pharmaceutics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Experimental Evaluation of Perfluorocarbon Aerosol Generation with Two Novel Nebulizer Prototypes

by
Iñigo Aramendia
1,
Unai Fernandez-Gamiz
1,*,
Alberto Lopez-Arraiza
2,
Carmen Rey-Santano
3,
Victoria Mielgo
3,
Francisco Jose Basterretxea
4,
Javier Sancho
1 and
Miguel Angel Gomez-Solaetxe
2
1
Nuclear Engineering and Fluid Mechanics Department, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Araba, Spain
2
Department of Nautical Science and Marine Systems, University of the Basque Country UPV/EHU, 48013 Portugalete, Bizkaia, Spain
3
Animal Research Unit, BioCruces Health Research Institute, 48903 Barakaldo, Bizkaia, Spain
4
Department of Physical Chemistry, University of the Basque Country UPV/EHU, 48940 Leioa, Bizkaia, Spain
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(1), 19; https://doi.org/10.3390/pharmaceutics11010019
Submission received: 19 November 2018 / Revised: 22 December 2018 / Accepted: 30 December 2018 / Published: 5 January 2019
Browse Figures
Versions Notes

Abstract

The potential of non-invasive ventilation procedures and new minimally invasive techniques has resulted in the research of alternative approaches as the aerosolization for the treatment of respiratory distress syndrome (RDS). The aim of this work was to design two nebulizer prototypes and to evaluate them studying the particle size distribution of the inhaled droplets generated with distilled water and two perfluorocarbons (PFCs). Different experiments were performed with driving pressures of 1–3 bar for each compound. An Aerodynamic Particle Sizer was used to measure the aerodynamic diameter (Da), the mass median aerodynamic diameter (MMAD) and the geometric standard deviation (GSD). The results showed that both prototypes produced heterodisperse aerosols with Da mean values in all cases below 5 µm. The initial experiments with distilled water showed MMAD values lower than 9 µm and up to 15 µm with prototype 1 and prototype 2, respectively. Regarding the PFCs, relatively uniform MMAD values close to 12 µm were achieved. The air delivery with outer lumens of prototype 1 presented more suitable mass distribution for the generation and delivery of a uniform aerosol than the two half-circular ring geometry proposed in the prototype 2.
Keywords: drug delivery; nebulizer; aerosol; aerodynamic particle sizer; particle size distribution drug delivery; nebulizer; aerosol; aerodynamic particle sizer; particle size distribution
Graphical Abstract

Share and Cite

MDPI and ACS Style

Aramendia, I.; Fernandez-Gamiz, U.; Lopez-Arraiza, A.; Rey-Santano, C.; Mielgo, V.; Basterretxea, F.J.; Sancho, J.; Gomez-Solaetxe, M.A. Experimental Evaluation of Perfluorocarbon Aerosol Generation with Two Novel Nebulizer Prototypes. Pharmaceutics 2019, 11, 19. https://doi.org/10.3390/pharmaceutics11010019

AMA Style

Aramendia I, Fernandez-Gamiz U, Lopez-Arraiza A, Rey-Santano C, Mielgo V, Basterretxea FJ, Sancho J, Gomez-Solaetxe MA. Experimental Evaluation of Perfluorocarbon Aerosol Generation with Two Novel Nebulizer Prototypes. Pharmaceutics. 2019; 11(1):19. https://doi.org/10.3390/pharmaceutics11010019

Chicago/Turabian Style

Aramendia, Iñigo, Unai Fernandez-Gamiz, Alberto Lopez-Arraiza, Carmen Rey-Santano, Victoria Mielgo, Francisco Jose Basterretxea, Javier Sancho, and Miguel Angel Gomez-Solaetxe. 2019. "Experimental Evaluation of Perfluorocarbon Aerosol Generation with Two Novel Nebulizer Prototypes" Pharmaceutics 11, no. 1: 19. https://doi.org/10.3390/pharmaceutics11010019

APA Style

Aramendia, I., Fernandez-Gamiz, U., Lopez-Arraiza, A., Rey-Santano, C., Mielgo, V., Basterretxea, F. J., Sancho, J., & Gomez-Solaetxe, M. A. (2019). Experimental Evaluation of Perfluorocarbon Aerosol Generation with Two Novel Nebulizer Prototypes. Pharmaceutics, 11(1), 19. https://doi.org/10.3390/pharmaceutics11010019

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop