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Pharmaceutics
Volume 11
Issue 10
10.3390/pharmaceutics11100518
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Review

Innovations in Pediatric Drug Formulations and Administration Technologies for Low Resource Settings

by
Stephen E. Gerrard
1,*,
Jennifer Walsh
2,
Niya Bowers
1,
Smita Salunke
3 and
Susan Hershenson
1
1
Global Health and Global Development Divisions, Bill and Melinda Gates Foundation, Seattle, WA 98109, USA
2
Jenny Walsh Consulting Ltd.; Nottingham NG1 1GF, UK
3
School of Pharmacy, University College London, London WC1N 1AX, UK
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(10), 518; https://doi.org/10.3390/pharmaceutics11100518
Submission received: 22 July 2019 / Revised: 1 October 2019 / Accepted: 1 October 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Paediatric Drug Delivery)
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Abstract

Despite advances in regulations and initiatives to increase pediatric medicine development, there is still an unmet need for age-appropriate medicines for children. The availability of pediatric formulations is particularly lacking in resource poor areas, due to, for example, area-specific disease burden and financial constraints, as well as disconnected supply chains and fragmented healthcare systems. The paucity of authorized pediatric medicines often results in the manipulation and administration of products intended for adults, with an increased risk of mis-dosing and adverse reactions. This article provides an overview of the some of the key difficulties associated with the development of pediatric medicines in both high and low resource areas, and highlights shared and location specific challenges and opportunities. The utilization of dispersible oral dosage forms and suppositories for low and middle-income countries (LMICs) are described in addition to other platform technologies that may in the future offer opportunities for future pediatric medicine development for low resource settings.
Keywords: pediatric; drug development; formulation; global health; dispersible; suppository pediatric; drug development; formulation; global health; dispersible; suppository
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MDPI and ACS Style

Gerrard, S.E.; Walsh, J.; Bowers, N.; Salunke, S.; Hershenson, S. Innovations in Pediatric Drug Formulations and Administration Technologies for Low Resource Settings. Pharmaceutics 2019, 11, 518. https://doi.org/10.3390/pharmaceutics11100518

AMA Style

Gerrard SE, Walsh J, Bowers N, Salunke S, Hershenson S. Innovations in Pediatric Drug Formulations and Administration Technologies for Low Resource Settings. Pharmaceutics. 2019; 11(10):518. https://doi.org/10.3390/pharmaceutics11100518

Chicago/Turabian Style

Gerrard, Stephen E., Jennifer Walsh, Niya Bowers, Smita Salunke, and Susan Hershenson. 2019. "Innovations in Pediatric Drug Formulations and Administration Technologies for Low Resource Settings" Pharmaceutics 11, no. 10: 518. https://doi.org/10.3390/pharmaceutics11100518

APA Style

Gerrard, S. E., Walsh, J., Bowers, N., Salunke, S., & Hershenson, S. (2019). Innovations in Pediatric Drug Formulations and Administration Technologies for Low Resource Settings. Pharmaceutics, 11(10), 518. https://doi.org/10.3390/pharmaceutics11100518

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