New Properties and Mitochondrial Targets of Polyphenol Agrimoniin as a Natural Anticancer and Preventive Agent
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Influence of Agrimoniin on Mitochondrial Respiration and SDH Activity
3.2. Influence of Agrimoniin on Calcium-Induced MPTP Opening
3.3. Effect of Agrimoniin on the Mitochondrial Swelling
3.4. Effect of Agrimoniin on the Mitochondrial Swelling in the Presence of Iron Ions
3.5. Cytotoxic Effect of Agrimoniin on Cancer Cell Lines
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
Abbreviations
Ag | agrimoniin |
ANT | adenylate translocase |
BHT | butylhydroxytoluene |
CRC | calcium retention capacity |
Cs A | cyclosporin A |
DNP | 2,4-Dinitrophenol |
DCPIP | 2,6-Dichlorophenolindophenol |
MPTP | mitochondrial permeability transition pore |
MTT | 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenytetrazolium bromide |
PMS | phenazinemethosulfate |
SDH | succinate dehydrogenase |
TPP+ | tetraphenylphosphonium |
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Fedotcheva, T.A.; Sheichenko, O.P.; Fedotcheva, N.I. New Properties and Mitochondrial Targets of Polyphenol Agrimoniin as a Natural Anticancer and Preventive Agent. Pharmaceutics 2021, 13, 2089. https://doi.org/10.3390/pharmaceutics13122089
Fedotcheva TA, Sheichenko OP, Fedotcheva NI. New Properties and Mitochondrial Targets of Polyphenol Agrimoniin as a Natural Anticancer and Preventive Agent. Pharmaceutics. 2021; 13(12):2089. https://doi.org/10.3390/pharmaceutics13122089
Chicago/Turabian StyleFedotcheva, Tatiana A., Olga P. Sheichenko, and Nadezhda I. Fedotcheva. 2021. "New Properties and Mitochondrial Targets of Polyphenol Agrimoniin as a Natural Anticancer and Preventive Agent" Pharmaceutics 13, no. 12: 2089. https://doi.org/10.3390/pharmaceutics13122089