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Pharmaceutics
Volume 13
Issue 7
10.3390/pharmaceutics13070937
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Article

Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM

by
Satyajeet Bhonsale
1,
Lewis Scott
2,
Mojtaba Ghadiri
2 and
Jan Van Impe
1,*
1
BioTeC+, Department of Chemical Engineering, Technology Campus Ghent, KU Leuven, Gebroeders de Smetstraat 1, 9000 Ghent, Belgium
2
School of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, UK
*
Author to whom correspondence should be addressed.
Pharmaceutics 2021, 13(7), 937; https://doi.org/10.3390/pharmaceutics13070937
Submission received: 19 May 2021 / Revised: 16 June 2021 / Accepted: 19 June 2021 / Published: 23 June 2021
(This article belongs to the Special Issue Recent Advances in Secondary Processing of Pharmaceutical Powders)
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Abstract

Spiral jet mills are ubiquitous in the pharmaceutical industry. Breakage and classification in spiral jet mills occur due to complex interactions between the fluid and the solid phases. The study of these interactions requires the use of computational fluid dynamics (CFD) for the fluid phase coupled with discrete element models (DEM) for the particle phase. In this study, we investigate particle dynamics in a 50-mm spiral jet mill through coupled CFD-DEM simulations. The simulations showed that the fluid was significantly decelerated by the presence of the particles in the milling chamber. Furthermore, we study the particle dynamics and collision statistics at two different operating conditions and three different particle loadings. As expected, the particle velocity was affected by both the particle loading and operating pressure. The particles moved slower at low pressures and high loadings. We also found that particle–particle collisions outnumbered particle–wall collisions.
Keywords: spiral jet mills; discrete element models; computational fluid dynamics spiral jet mills; discrete element models; computational fluid dynamics

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MDPI and ACS Style

Bhonsale, S.; Scott, L.; Ghadiri, M.; Van Impe, J. Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM. Pharmaceutics 2021, 13, 937. https://doi.org/10.3390/pharmaceutics13070937

AMA Style

Bhonsale S, Scott L, Ghadiri M, Van Impe J. Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM. Pharmaceutics. 2021; 13(7):937. https://doi.org/10.3390/pharmaceutics13070937

Chicago/Turabian Style

Bhonsale, Satyajeet, Lewis Scott, Mojtaba Ghadiri, and Jan Van Impe. 2021. "Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM" Pharmaceutics 13, no. 7: 937. https://doi.org/10.3390/pharmaceutics13070937

APA Style

Bhonsale, S., Scott, L., Ghadiri, M., & Van Impe, J. (2021). Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM. Pharmaceutics, 13(7), 937. https://doi.org/10.3390/pharmaceutics13070937

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