Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose® 80, CombiLac®, MicroceLac® 100, and StarLac®
, Petra Svačinová 2,†, Jan Elbl 1, Sylvie Pavloková 1, Barbora Blahová Prudilová 3, Zdeňka Šklubalová 2 and Aleš Franc 1,*Round 1
Reviewer 1 Report
The presented article deals with current issues in the field of research of excipients for ODT formulations. In principle, I have no factual comments on the text presented, except for a few details.
1, Figure 7B contains an incorrect description of the y-axis. Please correct this mistake to improve the quality of the manuscript.
2, Please add a reference to the measurement issue of Angle of repose.
Author Response
Dear Madam or Sir,
we would like to thank you for your beneficial comments and suggestions. The manuscript was corrected in accordance with them. The manuscript is corrected in the form of revisions. We hope you will find our manuscript interesting and in acceptable form for publishing in your journal after our revision.
Please see the attachment.
Author Response File: 
Author Response.docx
Reviewer 2 Report
In this manuscript, the authors have typically compared the physical and chemical properties of CPE (Cellactose® 80, CombiLac®, MicroceLac® 100, and StarLac®). In addition, the authors in particular focus on their application in direct compression for tablet fabrication. However, partial properties of these CPEs have been previously identified and recommended by the manufacturer. The authors have to impose their aim and novelty of this study and meanwhile added some discussion in this manuscript.
Author Response
Dear Madam or Sir,
we would like to thank you for your beneficial comments and suggestions. The manuscript was corrected in accordance with them. The manuscript is corrected in the form of revisions. We hope you will find our manuscript interesting and in acceptable form for publishing in your journal after our revision.
Please see the attachment.
Author Response File: Author Response.docx
Reviewer 3 Report
This article in well written and extensive studies were performed for this project. The Materials and Methods are extremely long and discuss many results. The test used are appropriate for the task. The information is significant for table manufacturers, however the reader gets lost on the long details. I suggest you use abbreviations for your 4 products so there is not repetition. Please make one or two paragraphs from the results in the conclusion or discussion and summarize in compact detail the findings. As with most technical detail articles, the reader learns a lot of good techniques and information about the excipients which aid in selection for different tablet formulations.
Line 846 change tablets damaged
Author Response
Dear Madam or Sir,
we would like to thank you for your beneficial comments and suggestions. The manuscript was corrected in accordance with them. The manuscript is corrected in the form of revisions. We hope you will find our manuscript interesting and in acceptable form for publishing in your journal after our revision.
Please see the attachment.
Author Response File: Author Response.docx
Round 2
Reviewer 2 Report
This modified version of the manuscript is simple but clearly explained the experimental methods and the results. It is suggested to be accepted and published.
