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Pharmaceutics
Volume 14
Issue 4
10.3390/pharmaceutics14040686
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Article

Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia

by
Tingting Zhu
1,
Xixi Yu
2,
Xin Yi
3,
Xiaoli Guo
1,
Longhao Li
4,
Yuanping Hao
2,* and
Wanchun Wang
1,2,*
1
School of Stomatology of Qingdao University, Qingdao 266003, China
2
Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao 266001, China
3
School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China
4
Department of Stomatology, School of Stomatology of Weifang Medical University, Weifang 261053, China
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2022, 14(4), 686; https://doi.org/10.3390/pharmaceutics14040686
Submission received: 9 February 2022 / Revised: 12 March 2022 / Accepted: 18 March 2022 / Published: 22 March 2022
(This article belongs to the Special Issue Advanced Colloidal Systems for Multimodal Drug Delivery)
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Abstract

The pain and fear caused by direct local injection of anesthetic or the poor experience with surface anesthetic cream increase the difficulty of clinical treatment for oral diseases. To address this problem, a hyaluronic acid microneedle patch (Li-HAMNs) that consists of fast-dissolving lidocaine hydrochloride (LDC)-loaded tips and a wet-adhesive backing layer made of polyvinyl alcohol (PVA)/carboxymethylcellulose sodium (CMC-Na) was fabricated to explore its potential use in dental topical anesthesia. Li-HAMNs could puncture the stratum corneum with an insertion depth of about 279 μm in the isolated porcine oral mucosal. The fast-dissolving tips could release LDC to improve the patients’ convenience and compliance. Importantly, the backing layer, which has good adhesion ability and water-absorbing properties, could surmount the contraction and extension of oral masticatory muscles and the saliva scour. In the tail flick test, the topical anesthesia efficacy of the Li-HAMNs group was much better than clinical lidocaine cream (EMLA cream, LDC, 1.2 mg) in spite of a relatively lower LDC dose with Li-HAMNs (LDC, 0.5 mg). It is believed that the proposed adhesive microneedle patch could enhance transmucosal delivery of anesthetics and thus open a new chapter in the painless treatment of oral diseases.
Keywords: adhesive microneedle; lidocaine; hyaluronic acid; topical anesthesia; oral mucosal; transdermal drug delivery adhesive microneedle; lidocaine; hyaluronic acid; topical anesthesia; oral mucosal; transdermal drug delivery

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MDPI and ACS Style

Zhu, T.; Yu, X.; Yi, X.; Guo, X.; Li, L.; Hao, Y.; Wang, W. Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia. Pharmaceutics 2022, 14, 686. https://doi.org/10.3390/pharmaceutics14040686

AMA Style

Zhu T, Yu X, Yi X, Guo X, Li L, Hao Y, Wang W. Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia. Pharmaceutics. 2022; 14(4):686. https://doi.org/10.3390/pharmaceutics14040686

Chicago/Turabian Style

Zhu, Tingting, Xixi Yu, Xin Yi, Xiaoli Guo, Longhao Li, Yuanping Hao, and Wanchun Wang. 2022. "Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia" Pharmaceutics 14, no. 4: 686. https://doi.org/10.3390/pharmaceutics14040686

APA Style

Zhu, T., Yu, X., Yi, X., Guo, X., Li, L., Hao, Y., & Wang, W. (2022). Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia. Pharmaceutics, 14(4), 686. https://doi.org/10.3390/pharmaceutics14040686

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