Next Article in Journal
Novel Nanoparticle-Based Treatment and Imaging Modalities
Previous Article in Journal
Nano-Hydroxyapatite/PLGA Mixed Scaffolds as a Tool for Drug Development and to Study Metastatic Prostate Cancer in the Bone
Previous Article in Special Issue
Development of α-Tocopherol Succinate-Based Nanostructured Lipid Carriers for Delivery of Paclitaxel
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceutics
Volume 15
Issue 1
10.3390/pharmaceutics15010243
pharmaceutics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Fabrication and Characterisation of 3D-Printed Triamcinolone Acetonide-Loaded Polycaprolactone-Based Ocular Implants

by
Febri Annuryanti
1,2,
Juan Domínguez-Robles
1,
Qonita Kurnia Anjani
1,
Muhammad Faris Adrianto
1,2,
Eneko Larrañeta
1 and
Raghu Raj Singh Thakur
1,*
1
Medical Biology Centre, School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
2
Faculty of Pharmacy, Airlangga University, Nanizar Zaman Joenoes Building, C Campus, Mulyorejo, Surabaya 60115, Indonesia
*
Author to whom correspondence should be addressed.
Pharmaceutics 2023, 15(1), 243; https://doi.org/10.3390/pharmaceutics15010243
Submission received: 12 October 2022 / Revised: 13 December 2022 / Accepted: 26 December 2022 / Published: 11 January 2023
(This article belongs to the Special Issue Nanotechnology in Ocular Drug Delivery)
Browse Figures
Versions Notes

Abstract

Triamcinolone acetonide (TA) is a corticosteroid that has been used to treat posterior segment eye diseases. TA is injected intravitreally in the management of neovascular disorders; however, frequent intravitreal injections result in many potential side effects and poor patient compliance. In this work, a 3D bioprinter was used to prepare polycaprolactone (PCL) implants loaded with TA. Implants were manufactured with different shapes (filament-, rectangular-, and circle-shaped) and drug loadings (5, 10, and 20%). The characterisation results showed that TA was successfully mixed and incorporated within the PCL matrix without using solvents, and drug content reached almost 100% for all formulations. The drug release data demonstrate that the filament-shaped implants (SA/V ratio~7.3) showed the highest cumulative drug release amongst all implant shapes over 180 days, followed by rectangular- (SA/V ratio~3.7) and circle-shaped implants (SA/V ratio~2.80). Most implant drug release data best fit the Korsmeyer–Peppas model, indicating that diffusion was the prominent release mechanism. Additionally, a biocompatibility study was performed; the results showed >90% cell viability, thus proving that the TA-loaded PCL implants were safe for ocular application.
Keywords: triamcinolone acetonide; polycaprolactone; intravitreal; implant; 3D bioscaffold printing triamcinolone acetonide; polycaprolactone; intravitreal; implant; 3D bioscaffold printing
Graphical Abstract

Share and Cite

MDPI and ACS Style

Annuryanti, F.; Domínguez-Robles, J.; Anjani, Q.K.; Adrianto, M.F.; Larrañeta, E.; Thakur, R.R.S. Fabrication and Characterisation of 3D-Printed Triamcinolone Acetonide-Loaded Polycaprolactone-Based Ocular Implants. Pharmaceutics 2023, 15, 243. https://doi.org/10.3390/pharmaceutics15010243

AMA Style

Annuryanti F, Domínguez-Robles J, Anjani QK, Adrianto MF, Larrañeta E, Thakur RRS. Fabrication and Characterisation of 3D-Printed Triamcinolone Acetonide-Loaded Polycaprolactone-Based Ocular Implants. Pharmaceutics. 2023; 15(1):243. https://doi.org/10.3390/pharmaceutics15010243

Chicago/Turabian Style

Annuryanti, Febri, Juan Domínguez-Robles, Qonita Kurnia Anjani, Muhammad Faris Adrianto, Eneko Larrañeta, and Raghu Raj Singh Thakur. 2023. "Fabrication and Characterisation of 3D-Printed Triamcinolone Acetonide-Loaded Polycaprolactone-Based Ocular Implants" Pharmaceutics 15, no. 1: 243. https://doi.org/10.3390/pharmaceutics15010243

APA Style

Annuryanti, F., Domínguez-Robles, J., Anjani, Q. K., Adrianto, M. F., Larrañeta, E., & Thakur, R. R. S. (2023). Fabrication and Characterisation of 3D-Printed Triamcinolone Acetonide-Loaded Polycaprolactone-Based Ocular Implants. Pharmaceutics, 15(1), 243. https://doi.org/10.3390/pharmaceutics15010243

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop