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Pharmaceutics
Volume 15
Issue 4
10.3390/pharmaceutics15041033
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Review
Peer-Review Record

Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children

Pharmaceutics 2023, 15(4), 1033; https://doi.org/10.3390/pharmaceutics15041033
by Klervi Golhen 1,*,†, Michael Buettcher 1,2,3,†, Jonas Kost 4, Jörg Huwyler 4 and Marc Pfister 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3:
Syed M.B. Asdaq
Pharmaceutics 2023, 15(4), 1033; https://doi.org/10.3390/pharmaceutics15041033
Submission received: 24 February 2023 / Revised: 17 March 2023 / Accepted: 20 March 2023 / Published: 23 March 2023
(This article belongs to the Special Issue Advance in Development of Patient-Centric Dosage Form, 2nd Edition)

Round 1

Reviewer 1 Report

elaborate more on the children perspective, i.e. with reference to their compliance to clinical trials

correct formulations at line 418

improve the conclusions

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This manuscript describes the pediatric drug delivery, especially orally fast disintegrating tablets foe infants and children. This review manuscript provides comprehensive information on child-friendly formulation at this point. Reviewer thinks the manuscript is to be overall well written. Not found any critical comments.

 I think this manuscript is acceptable for publication by addressing the following minor points.

 Please correct the numbering of case studies so that it starts at 1.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

The review article on meeting the challenges of pediatric drug delivery is interesting.

I recommend that the authors include a section on barriers to pediatric drug development, emphasizing ethical concerns, economic barriers, and industry perspectives on barriers to pediatric drug development.

I suggest making the article more reader-friendly if they can summarize somewhere why a significant number of current drug formulations are not suitable for children of different age groups.

The inclusion of a clinical case study is an excellent step.

I suggest that authors include a simple table where they can list out the clinical and technological challenges, current practices to overcome them, and then the recommendations in the last column.

A discussion section is missing in the article where they can summarize the details given in several sections.

Also, it would be good to include a section on methods, where they can explain the methods applied for extracting the resources used in this article.

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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