In Situ Synthesis of a Tumor-Microenvironment-Responsive Chemotherapy Drug
Abstract
:1. Introduction
2. Materials and Methods
2.1. Synthesis of MS-Cu Nanospheres
2.2. Synthesis of PEG-MS-Cu Nanospheres
2.3. Characterization of MS-Cu Nanospheres
2.4. In Vitro Cytotoxicity of MS-Cu Nanospheres and DSF; In Vitro Reactive Oxygen Species (ROS) Generation
2.5. In Vitro Safety of MS-Cu and PEG-MS-Cu
2.6. In Vivo Antitumor Efficacy of Combined Oral Administration of DSF and Intratumoral Administration of MS-Cu Nanospheres
2.7. In Vivo Antitumor Efficacy of Combined Oral Administration of DSF and Intravenous Administration of PEG-MS-Cu Nanospheres
2.8. Statistical Analysis
3. Results and Discussion
3.1. Physicochemical Characterization of MS-Cu Nanospheres
3.2. In Vitro Cytotoxicity of MS-Cu Nanospheres and DSF
3.3. In Vivo Antitumor Efficacy of Combined Oral Administration of DSF and Intratumoral Administration of MS-Cu Nanospheres
3.4. In Vivo Antitumor Efficacy and Safety of Combined Oral Administration of DSF and Intravenous Administration of PEG-MS-Cu Nanospheres
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Wang, X.; Oyane, A.; Inose, T.; Nakamura, M. In Situ Synthesis of a Tumor-Microenvironment-Responsive Chemotherapy Drug. Pharmaceutics 2023, 15, 1316. https://doi.org/10.3390/pharmaceutics15041316
Wang X, Oyane A, Inose T, Nakamura M. In Situ Synthesis of a Tumor-Microenvironment-Responsive Chemotherapy Drug. Pharmaceutics. 2023; 15(4):1316. https://doi.org/10.3390/pharmaceutics15041316
Chicago/Turabian StyleWang, Xiupeng, Ayako Oyane, Tomoya Inose, and Maki Nakamura. 2023. "In Situ Synthesis of a Tumor-Microenvironment-Responsive Chemotherapy Drug" Pharmaceutics 15, no. 4: 1316. https://doi.org/10.3390/pharmaceutics15041316