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Volume 16
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10.3390/pharmaceutics16040490
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Article

Synergistic Effects of Chemotherapy and Phototherapy on Ovarian Cancer Using Follicle-Stimulating Hormone Receptor-Mediated Liposomes Co-Loaded with SN38 and IR820

by
Lina Pian
1,2,†,
Bowen Zeng
3,4,†,
Nuoya Wang
3,4,
Shuangqing Wang
3,4,
Hao Wu
3,4,
Hongshuang Wan
3,4,
Liqing Chen
3,4,
Wei Huang
3,4,
Zhonggao Gao
3,4,*,
Dan Jin
1,2,* and
Mingji Jin
3,4
1
Immunology Biology Key Laboratory, Yanbian University, Yanji 133000, China
2
Department of Gynecology, Yanbian University Hospital, Yanji 133000, China
3
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
4
Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceutics 2024, 16(4), 490; https://doi.org/10.3390/pharmaceutics16040490
Submission received: 2 February 2024 / Revised: 14 March 2024 / Accepted: 28 March 2024 / Published: 2 April 2024
(This article belongs to the Special Issue Polymer Nanoparticles for the Delivery of Anticancer Drugs, 3rd Edition)
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Abstract

We have developed an ovarian cancer-targeted drug delivery system based on a follicle-stimulating hormone receptor (FSHR) peptide. The lipophilic chemotherapeutic drug SN38 and the photosensitizer IR820 were loaded into the phospholipid bilayer of liposomes. The combination of chemotherapy and phototherapy has become a promising strategy to improve the therapeutic effect of chemotherapy drugs on solid tumors. IR820 can be used for photodynamic therapy (PDT), effectively converting near-infrared light (NIR) into heat and producing reactive oxygen species (ROS), causing damage to intracellular components and leading to cell death. In addition, PDT generates heat in near-infrared, thereby enhancing the sensitivity of tumors to chemotherapy drugs. FSH liposomes loaded with SN38 and IR820 (SN38/IR820-Lipo@FSH) were prepared using thin-film hydration-sonication. FSH peptide binding was analyzed using 1H NMR spectrum and Maldi-Tof. The average size and zeta potential of SN38/IR820-Lipo@FSH were 105.1 ± 1.15 nm (PDI: 0.204 ± 0.03) and −27.8 ± 0.42 mV, respectively. The encapsulation efficiency of SN38 and IR820 in SN38/IR820-Lipo@FSH liposomes were 90.2% and 91.5%, respectively, and their release was slow in vitro. FSH significantly increased the uptake of liposomes, inhibited cell proliferation, and induced apoptosis in A2780 cells. Moreover, SN38/IR820-Lipo@FSH exhibited better tumor-targeting ability and anti-ovarian cancer activity in vivo when compared with non-targeted SN38/IR820-Lipo. The combination of chemotherapy and photodynamic treatment based on an FSH peptide-targeted delivery system may be an effective approach to treating ovarian cancer.
Keywords: FSHβ (33–53) peptide; ovarian cancer; targeting therapy; PDT; SN38 FSHβ (33–53) peptide; ovarian cancer; targeting therapy; PDT; SN38

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MDPI and ACS Style

Pian, L.; Zeng, B.; Wang, N.; Wang, S.; Wu, H.; Wan, H.; Chen, L.; Huang, W.; Gao, Z.; Jin, D.; et al. Synergistic Effects of Chemotherapy and Phototherapy on Ovarian Cancer Using Follicle-Stimulating Hormone Receptor-Mediated Liposomes Co-Loaded with SN38 and IR820. Pharmaceutics 2024, 16, 490. https://doi.org/10.3390/pharmaceutics16040490

AMA Style

Pian L, Zeng B, Wang N, Wang S, Wu H, Wan H, Chen L, Huang W, Gao Z, Jin D, et al. Synergistic Effects of Chemotherapy and Phototherapy on Ovarian Cancer Using Follicle-Stimulating Hormone Receptor-Mediated Liposomes Co-Loaded with SN38 and IR820. Pharmaceutics. 2024; 16(4):490. https://doi.org/10.3390/pharmaceutics16040490

Chicago/Turabian Style

Pian, Lina, Bowen Zeng, Nuoya Wang, Shuangqing Wang, Hao Wu, Hongshuang Wan, Liqing Chen, Wei Huang, Zhonggao Gao, Dan Jin, and et al. 2024. "Synergistic Effects of Chemotherapy and Phototherapy on Ovarian Cancer Using Follicle-Stimulating Hormone Receptor-Mediated Liposomes Co-Loaded with SN38 and IR820" Pharmaceutics 16, no. 4: 490. https://doi.org/10.3390/pharmaceutics16040490

APA Style

Pian, L., Zeng, B., Wang, N., Wang, S., Wu, H., Wan, H., Chen, L., Huang, W., Gao, Z., Jin, D., & Jin, M. (2024). Synergistic Effects of Chemotherapy and Phototherapy on Ovarian Cancer Using Follicle-Stimulating Hormone Receptor-Mediated Liposomes Co-Loaded with SN38 and IR820. Pharmaceutics, 16(4), 490. https://doi.org/10.3390/pharmaceutics16040490

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