Physicochemical Stability of Hospital Parenteral Nutrition Solutions: Effect of Changes in Composition and Storage Protocol
Abstract
:1. Introduction
2. Materials and Methods
2.1. Sample Preparation and Storage
2.2. Study of Droplet Diameter
2.3. Density, Viscosity and pH Variation
2.4. Visual Controls
2.5. Statistical Analysis
3. Results
3.1. Droplet Diameter
3.2. pH
3.3. Viscosity and Density
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sample | N (g/L) | Prot (g/L) | Gluc (g/L) | Lip (g/L) | Na (mMol/L) | K (mMol/L) | Mg (mMol/L) | Ca (mMol/L) | P (mMol/L) | OSM (mOsm/L) | CAN (mMol/L) |
---|---|---|---|---|---|---|---|---|---|---|---|
PN BASE | 4.00 | 25.00 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 1030.00 | 2020.00 |
PN1 | 4.00 | 25.00 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 50.00 | 12.50 | 1130.00 | 3620.00 |
PN2 | 4.00 | 25.00 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 62.50 | 12.50 | 1180.00 | 4420.00 |
PN3 | 4.00 | 25.00 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 75.00 | 12.50 | 1230.00 | 5220.00 |
PN4 | 4.00 | 25.00 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 87.50 | 12.50 | 1280.00 | 6020.00 |
PN5 | 4.00 | 25.00 | 75.00 | 20.00 | 40.00 | 60.00 | 12.50 | 25.00 | 12.50 | 1060.00 | 2500.00 |
PN6 | 4.00 | 25.00 | 75.00 | 20.00 | 40.00 | 60.00 | 25.00 | 25.00 | 12.50 | 1110.00 | 3300.00 |
PN7 | 4.00 | 25.00 | 75.00 | 20.00 | 40.00 | 60.00 | 37.50 | 25.00 | 12.50 | 1160.00 | 4100.00 |
PN8 | 4.00 | 25.00 | 75.00 | 20.00 | 40.00 | 60.00 | 50.00 | 25.00 | 12.50 | 1210.00 | 4900.00 |
PN9 | 4.00 | 25.00 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 25.00 | 20.00 | 1043.50 | 2020.00 |
PN10 | 4.00 | 25.00 | 75.00 | 20.00 | 48.00 | 60.00 | 5.00 | 25.00 | 30.00 | 1101.50 | 2028.00 |
PN11 | 4.00 | 25.00 | 75.00 | 20.00 | 80.00 | 60.00 | 5.00 | 25.00 | 50.00 | 1217.50 | 2060.00 |
PN12 | 4.00 | 25.00 | 75.00 | 20.00 | 120.00 | 60.00 | 5.00 | 25.00 | 100.00 | 1507.50 | 2100.00 |
PN13 | 4.00 | 25.00 | 75.00 | 15.00 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 1015.00 | 2020.00 |
PN14 | 4.00 | 25.00 | 75.00 | 10.00 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 1000.00 | 2020.00 |
PN15 | 4.00 | 25.00 | 75.00 | 5.00 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 985.00 | 2020.00 |
PN16 | 4.00 | 25.00 | 75.00 | 2.50 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 977.50 | 2020.00 |
PN17 | 4.00 | 25.00 | 75.00 | 1.24 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 973.75 | 2020.00 |
PN18 | 3.50 | 21.87 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 995.63 | 2020.00 |
PN19 | 3.00 | 18.75 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 961.25 | 2020.00 |
PN20 | 2.50 | 15.62 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 926.88 | 2020.00 |
PN21 | 1.50 | 9.37 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 858.13 | 2020.00 |
PN22 | 0.00 | 0.00 | 75.00 | 20.00 | 40.00 | 60.00 | 5.00 | 25.00 | 12.50 | 755.00 | 2020.00 |
Sample | Day 1 | Day 3 | Day 10 | Day 14 | |||
---|---|---|---|---|---|---|---|
4 °C | 4 °C | RT | 4 °C | RT | 4 °C | RT | |
PN13 | 1.415 ± 0.004 | 1.402 ± 0.003 | 1.394 ± 0.003 | 1.399 ± 0.003 | 1.397 ± 0.004 | 1.411 ± 0.007 | 1.394 ± 0.004 |
PN14 | 1.365 ± 0.008 | 1.361 ± 0.005 | 1.368 ± 0.005 | 1.369 ± 0.004 | 1.365 ± 0.004 | 1.375 ± 0.003 | 1.387 ± 0.005 |
PN15 | 1.370 ± 0.004 | 1.344 ± 0.003 | 1.343 ± 0.004 | 1.347 ± 0.006 | 1.343 ± 0.004 | 1.357 ± 0.004 | 1.351 ± 0.004 |
PN16 | 1.343 ± 0.004 | 1.329 ± 0.003 | 1.321 ± 0.005 | 1.334 ± 0.005 | 1.356 ± 0.002 | 1.334 ± 0.005 | 1.331 ± 0.004 |
PN17 | 1.327 ± 0.005 | 1.316 ± 0.003 | 1.316 ± 0.003 | 1.320 ± 0.005 | 1.346 ± 0.003 | 1.320 ± 0.004 | 1.318 ± 0.003 |
Sample | Day 1 | Day 3 | Day 10 | Day 14 | |||
---|---|---|---|---|---|---|---|
4 °C | 4 °C | RT | 4 °C | RT | 4 °C | RT | |
PN13 | 1.045 | 1.049 | 1.045 | 1.049 | 1.045 | 1.045 | 1.045 |
PN14 | 1.044 | 1.044 | 1.044 | 1.044 | 1.044 | 1.044 | 1.044 |
PN15 | 1.045 | 1.045 | 1.045 | 1.045 | 1.045 | 1.045 | 1.045 |
PN16 | 1.045 | 1.045 | 1.045 | 1.045 | 1.045 | 1.046 | 1.045 |
PN17 | 1.045 | 1.045 | 1.045 | 1.045 | 1.045 | 1.045 | 1.045 |
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Otero-Millán, L.; Bea-Mascato, B.; Legido Soto, J.L.; Martínez-López-De-Castro, N.; Lago-Rivero, N. Physicochemical Stability of Hospital Parenteral Nutrition Solutions: Effect of Changes in Composition and Storage Protocol. Pharmaceutics 2024, 16, 572. https://doi.org/10.3390/pharmaceutics16050572
Otero-Millán L, Bea-Mascato B, Legido Soto JL, Martínez-López-De-Castro N, Lago-Rivero N. Physicochemical Stability of Hospital Parenteral Nutrition Solutions: Effect of Changes in Composition and Storage Protocol. Pharmaceutics. 2024; 16(5):572. https://doi.org/10.3390/pharmaceutics16050572
Chicago/Turabian StyleOtero-Millán, Luis, Brais Bea-Mascato, Jose Luis Legido Soto, Noemi Martínez-López-De-Castro, and Natividad Lago-Rivero. 2024. "Physicochemical Stability of Hospital Parenteral Nutrition Solutions: Effect of Changes in Composition and Storage Protocol" Pharmaceutics 16, no. 5: 572. https://doi.org/10.3390/pharmaceutics16050572
APA StyleOtero-Millán, L., Bea-Mascato, B., Legido Soto, J. L., Martínez-López-De-Castro, N., & Lago-Rivero, N. (2024). Physicochemical Stability of Hospital Parenteral Nutrition Solutions: Effect of Changes in Composition and Storage Protocol. Pharmaceutics, 16(5), 572. https://doi.org/10.3390/pharmaceutics16050572