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Pharmaceutics
Volume 17
Issue 1
10.3390/pharmaceutics17010129
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Article

Prilling as an Effective Tool for Manufacturing Submicrometric and Nanometric PLGA Particles for Controlled Drug Delivery to Wounds: Stability and Curcumin Release

by
Chiara De Soricellis
,
Chiara Amante
,
Paola Russo
,
Rita Patrizia Aquino
and
Pasquale Del Gaudio
*
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy
*
Author to whom correspondence should be addressed.
Pharmaceutics 2025, 17(1), 129; https://doi.org/10.3390/pharmaceutics17010129
Submission received: 16 December 2024 / Revised: 13 January 2025 / Accepted: 14 January 2025 / Published: 17 January 2025
(This article belongs to the Special Issue Advances in Drug Delivery Systems for the Treatment of Chronic Wound Healing)
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Abstract

Background/Objectives: This study investigates for the first time the use of the prilling technique in combination with solvent evaporation to produce nano- and submicrometric PLGA particles to deliver properly an active pharmaceutical ingredient. Curcumin (CCM), a hydrophobic compound classified under BCS (Biopharmaceutics Classification System) class IV, was selected as the model drug. Methods: Key process parameters, including polymer concentration, solvent type, nozzle size, and surfactant levels, were optimized to obtain stable particles with a narrow size distribution determined by DLS analysis. Results: Particles mean diameter (d50) 316 and 452 nm, depending on drug-loaded cargo as Curcumin-loaded PLGA nanoparticles demonstrated high encapsulation efficiency, assessed via HPLC analysis, stability, and controlled release profiles. In vitro studies revealed a faster release for lower drug loadings (90% release in 6 h) compared to sustained release over 7 days for higher-loaded nanoparticles, attributed to polymer degradation and drug-polymer interactions on the surface of the particles, as confirmed by FTIR analyses. Conclusions: These findings underline the potential of this scalable technique for biomedical applications, offering a versatile platform for designing drug delivery systems with tailored release characteristics.
Keywords: prilling; solvent evaporation; nanoparticles; submicrometric particles; PLGA; curcumin prilling; solvent evaporation; nanoparticles; submicrometric particles; PLGA; curcumin

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MDPI and ACS Style

De Soricellis, C.; Amante, C.; Russo, P.; Aquino, R.P.; Del Gaudio, P. Prilling as an Effective Tool for Manufacturing Submicrometric and Nanometric PLGA Particles for Controlled Drug Delivery to Wounds: Stability and Curcumin Release. Pharmaceutics 2025, 17, 129. https://doi.org/10.3390/pharmaceutics17010129

AMA Style

De Soricellis C, Amante C, Russo P, Aquino RP, Del Gaudio P. Prilling as an Effective Tool for Manufacturing Submicrometric and Nanometric PLGA Particles for Controlled Drug Delivery to Wounds: Stability and Curcumin Release. Pharmaceutics. 2025; 17(1):129. https://doi.org/10.3390/pharmaceutics17010129

Chicago/Turabian Style

De Soricellis, Chiara, Chiara Amante, Paola Russo, Rita Patrizia Aquino, and Pasquale Del Gaudio. 2025. "Prilling as an Effective Tool for Manufacturing Submicrometric and Nanometric PLGA Particles for Controlled Drug Delivery to Wounds: Stability and Curcumin Release" Pharmaceutics 17, no. 1: 129. https://doi.org/10.3390/pharmaceutics17010129

APA Style

De Soricellis, C., Amante, C., Russo, P., Aquino, R. P., & Del Gaudio, P. (2025). Prilling as an Effective Tool for Manufacturing Submicrometric and Nanometric PLGA Particles for Controlled Drug Delivery to Wounds: Stability and Curcumin Release. Pharmaceutics, 17(1), 129. https://doi.org/10.3390/pharmaceutics17010129

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