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Neurology International
Volume 10
Issue 3
10.4081/ni.2018.7737
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

Treatment of Levodopa-Induced Dyskinesia with Vitamin D: A Randomized, Double-Blind, Placebo-Controlled Trial

by
Amir Hassan Habibi
,
Arezo Anamoradi
,
Gholam Ali Shahidi
,
Saeed Razmeh
*,
Elham Alizadeh
and
Karim Moradian Kokhedan
Iran University of Medical Sciences, Tehran, Iran
*
Author to whom correspondence should be addressed.
Neurol. Int. 2018, 10(3), 7737; https://doi.org/10.4081/ni.2018.7737
Submission received: 28 April 2018 / Revised: 28 April 2018 / Accepted: 3 June 2018 / Published: 1 October 2018

Abstract

Dyskinesia refers to any involuntary movement, such as chorea, dystonia, ballism that affect any part of the body. Levodopa-induced dyskinesia is a neurological disorder that afflicts many patients with Parkinson disease usually 5 years after the onset of levodopa therapy and can cause severe disability. The pathophysiology of this dyskinesia is complex and not fully understood. However, the association between vitamin D and Parkinson disease is interesting. The present study was conducted to evaluate the effect of vitamin D on levodopa induced dyskinesia in patients with Parkinson’s disease .In this Double blind clinical trial, 120 patients with PD divided into two groups randomly, vitamin D and placebo group. A dose of 1000 IU/d was selected, Demographic information is registered. In the first visit, three variables have been measured which were the duration, severity of dyskinesia and unified Parkinson’s disease rating scale (UPDRS). These variables were measured again after 3 months and the data was analyzed using SPSS 22. There are no differences between two groups after 3 months. This study revealed, vitamin D has no effects on improvement of levodopa induced dyskinesia.
Keywords: Levodopa-induced dyskinesia; vitamin D; Parkinson’s disease Levodopa-induced dyskinesia; vitamin D; Parkinson’s disease

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MDPI and ACS Style

Habibi, A.H.; Anamoradi, A.; Shahidi, G.A.; Razmeh, S.; Alizadeh, E.; Moradian Kokhedan, K. Treatment of Levodopa-Induced Dyskinesia with Vitamin D: A Randomized, Double-Blind, Placebo-Controlled Trial. Neurol. Int. 2018, 10, 7737. https://doi.org/10.4081/ni.2018.7737

AMA Style

Habibi AH, Anamoradi A, Shahidi GA, Razmeh S, Alizadeh E, Moradian Kokhedan K. Treatment of Levodopa-Induced Dyskinesia with Vitamin D: A Randomized, Double-Blind, Placebo-Controlled Trial. Neurology International. 2018; 10(3):7737. https://doi.org/10.4081/ni.2018.7737

Chicago/Turabian Style

Habibi, Amir Hassan, Arezo Anamoradi, Gholam Ali Shahidi, Saeed Razmeh, Elham Alizadeh, and Karim Moradian Kokhedan. 2018. "Treatment of Levodopa-Induced Dyskinesia with Vitamin D: A Randomized, Double-Blind, Placebo-Controlled Trial" Neurology International 10, no. 3: 7737. https://doi.org/10.4081/ni.2018.7737

APA Style

Habibi, A. H., Anamoradi, A., Shahidi, G. A., Razmeh, S., Alizadeh, E., & Moradian Kokhedan, K. (2018). Treatment of Levodopa-Induced Dyskinesia with Vitamin D: A Randomized, Double-Blind, Placebo-Controlled Trial. Neurology International, 10(3), 7737. https://doi.org/10.4081/ni.2018.7737

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