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Neurology International
Volume 14
Issue 2
10.3390/neurolint14020032
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Review

Ischemic Stroke and SARS-CoV-2 Infection: The Bidirectional Pathology and Risk Morbidities

by
Vishal Chavda
1,
Bipin Chaurasia
2,
Alessandro Fiorindi
3,
Giuseppe E. Umana
4,
Bingwei Lu
1 and
Nicola Montemurro
5,*
1
Department of Pathology, Stanford School of Medicine, Stanford University Medical Center, San Francisco, CA 94305, USA
2
Department of Neurosurgery, Bhawani Hospital and Research Center, Birgunj 44300, Nepal
3
Neurosurgery, SpedaliCivili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25100 Brescia, Italy
4
Department of Neurosurgery, Trauma and Gamma-Knife Center, Cannizzaro Hospital, 95100 Catania, Italy
5
Department of Neurosurgery, Azienda Ospedaliera Universitaria Pisana (AOUP), University of Pisa, 56100 Pisa, Italy
*
Author to whom correspondence should be addressed.
Neurol. Int. 2022, 14(2), 391-405; https://doi.org/10.3390/neurolint14020032
Submission received: 21 March 2022 / Revised: 16 April 2022 / Accepted: 22 April 2022 / Published: 24 April 2022
(This article belongs to the Special Issue Neurological Aspects of COVID-19: What We Knew Then, What We Know Now, & What We Need to Prepare for in the Future)
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Abstract

Stroke is a fatal morbidity that needs emergency medical admission and immediate medical attention. COVID-19 ischemic brain damage is closely associated with common neurological symptoms, which are extremely difficult to treat medically, and risk factors. We performed literature research about COVID-19 and ischemia in PubMed, MEDLINE, and Scopus for this current narrative review. We discovered parallel manifestations of SARS-CoV-19 infection and brain ischemia risk factors. In published papers, we discovered a similar but complex pathophysiology of SARS-CoV-2 infection and stroke pathology. A patient with other systemic co-morbidities, such as diabetes, hypertension, or any respiratory disease, has a fatal combination in intensive care management when infected with SARS-CoV-19. Furthermore, due to their shared risk factors, COVID-19 and stroke are a lethal combination for medical management to treat. In this review, we discuss shared pathophysiology, adjuvant risk factors, challenges, and advancements in stroke-associated COVID-19 therapeutics.
Keywords: COVID-19; anti-coagulants; ischemia; SARS-CoV-2; therapeutics; neurology; neurosurgery; stroke COVID-19; anti-coagulants; ischemia; SARS-CoV-2; therapeutics; neurology; neurosurgery; stroke

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MDPI and ACS Style

Chavda, V.; Chaurasia, B.; Fiorindi, A.; Umana, G.E.; Lu, B.; Montemurro, N. Ischemic Stroke and SARS-CoV-2 Infection: The Bidirectional Pathology and Risk Morbidities. Neurol. Int. 2022, 14, 391-405. https://doi.org/10.3390/neurolint14020032

AMA Style

Chavda V, Chaurasia B, Fiorindi A, Umana GE, Lu B, Montemurro N. Ischemic Stroke and SARS-CoV-2 Infection: The Bidirectional Pathology and Risk Morbidities. Neurology International. 2022; 14(2):391-405. https://doi.org/10.3390/neurolint14020032

Chicago/Turabian Style

Chavda, Vishal, Bipin Chaurasia, Alessandro Fiorindi, Giuseppe E. Umana, Bingwei Lu, and Nicola Montemurro. 2022. "Ischemic Stroke and SARS-CoV-2 Infection: The Bidirectional Pathology and Risk Morbidities" Neurology International 14, no. 2: 391-405. https://doi.org/10.3390/neurolint14020032

APA Style

Chavda, V., Chaurasia, B., Fiorindi, A., Umana, G. E., Lu, B., & Montemurro, N. (2022). Ischemic Stroke and SARS-CoV-2 Infection: The Bidirectional Pathology and Risk Morbidities. Neurology International, 14(2), 391-405. https://doi.org/10.3390/neurolint14020032

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