Effect Comparison of E-Cigarette and Traditional Smoking and Association with Stroke—A Cross-Sectional Study of NHANES
, Neel Patel 1, Mahika Khurana 2, Akshada Parulekar 3, Amrapali Patel 4, Juan Fernando Ortiz 5, Rutul Patel 6, Eseosa Urhoghide 7, Anuja Mistry 6, Arpita Bhriguvanshi 8, Mohammed Abdulqader 9, Neev Mehta 10, Kogulavadanan Arumaithurai 11 and Shamik Shah 12
Round 1
Reviewer 1 Report
the article by Patel et al titled "Effect comparison of E-cigarette and Traditional Smoking and association with stroke - a cross-sectional study of NHANES" aims to assess the relation between e-cigarettes smoking and stroke.
This is a nice study where several comorbidities were included and I am a bit surprised that some major comorbid conditions such as diabetes/ obesity etc where shown to be affecting the incidence. The authors need to discuss in the manuscript.
Also, in the limitations, the authors should highlight the different kind of e-cigarettes and how these can contribute to the stroke occurrence as these e-cigarettes have different constituents. Also, the frequency and the time of the day these cohorts where vaping should be included in the different variables assessed.
Author Response
Dear Reviewer
I appreciate your time and efforts to make this manuscript more accurate and reader friendly.
Attached is the respond to your comments.
- This is a nice study where several comorbidities were included and I am a bit surprised that some major comorbid conditions such as diabetes/ obesity etc where shown to be affecting the incidence. The authors need to discuss in the manuscript.
We used comorbidities like T2DM, HTN, TG, LDL etc to adjust the models to get accurate association between stroke and e cig but study was strictly designed to evaluate role of e cig.
- Also, in the limitations, the authors should highlight the different kind of e-cigarettes and how these can contribute to the stroke occurrence as these e-cigarettes have different constituents.
Have added in the discussion section.
- Also, the frequency and the time of the day these cohorts where vaping should be included in the different variables assessed.
As we did not have such data, we put it in the limitation section.
Thank you
Reviewer 2 Report
The paper is very interesting and focuses on aspects that we probably expected with the replacement of traditional smoke by new solutions. I have only one question for the authors: Was the risk assessed independently of other risk factors present (if any) in the populations studied?
Author Response
Dear Reviewer
I appreciate your time and efforts to make this manuscript more accurate and reader friendly.
Attached is the respond to your comments.
- Was the risk assessed independently of other risk factors present (if any) in the populations studied?
Yes the regression models were adjusted to demographic variables like, age, gender, race, annual household income, and comorbidities.
Thanks
