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Neurology International
Volume 3
Issue 2
10.4081/ni.2011.e10
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Review

Behavioral Outcome Measures Used for Human Neural Stem Cell Transplantation in Rat Stroke Models

by
Matthew B. Jensen
*,
Dong Y. Han
,
Abdullah Al Sawaf
and
Rajeev Krishnaney-Davison
Comprehensive Stroke Program, Department of Neurology, School of Medicine and Public Health, University of Wisconsin, 1685 Highland Ave, room 7273, Madison, WI 53705-2281, USA
*
Author to whom correspondence should be addressed.
Neurol. Int. 2011, 3(2), e10; https://doi.org/10.4081/ni.2011.e10
Submission received: 20 April 2011 / Revised: 21 April 2011 / Accepted: 30 August 2011 / Published: 22 September 2011

Abstract

Stroke is a leading cause of death and disability, leading to the development of various stroke models to test new treatments, most commonly in the rat. Human stroke trials focus on disability, related primarily to neurological deficits. To better model the clinical application of these treatments, many behavioral tests have been developed using the rat stroke model. We performed a systematic review of all the behavioral outcome measures used in published studies of human neural stem cell transplantation in rat stroke models. The reviewed tests include motor, sensory, cognitive, activity, and combination tests. For each test, we give a brief description, trace the origin of the test, and discuss test performance in the reviewed studies. We conclude that while many behavioral tests are available for this purpose, there does not appear to be consensus on an optimal testing strategy.
Keywords: stroke; rat; animal model; behavior; stem cell; transplantation stroke; rat; animal model; behavior; stem cell; transplantation

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MDPI and ACS Style

Jensen, M.B.; Han, D.Y.; Al Sawaf, A.; Krishnaney-Davison, R. Behavioral Outcome Measures Used for Human Neural Stem Cell Transplantation in Rat Stroke Models. Neurol. Int. 2011, 3, e10. https://doi.org/10.4081/ni.2011.e10

AMA Style

Jensen MB, Han DY, Al Sawaf A, Krishnaney-Davison R. Behavioral Outcome Measures Used for Human Neural Stem Cell Transplantation in Rat Stroke Models. Neurology International. 2011; 3(2):e10. https://doi.org/10.4081/ni.2011.e10

Chicago/Turabian Style

Jensen, Matthew B., Dong Y. Han, Abdullah Al Sawaf, and Rajeev Krishnaney-Davison. 2011. "Behavioral Outcome Measures Used for Human Neural Stem Cell Transplantation in Rat Stroke Models" Neurology International 3, no. 2: e10. https://doi.org/10.4081/ni.2011.e10

APA Style

Jensen, M. B., Han, D. Y., Al Sawaf, A., & Krishnaney-Davison, R. (2011). Behavioral Outcome Measures Used for Human Neural Stem Cell Transplantation in Rat Stroke Models. Neurology International, 3(2), e10. https://doi.org/10.4081/ni.2011.e10

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