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Neurology International
Volume 5
Issue 1
10.4081/ni.2013.e3
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Humoral Immune Activation in Amyotrophic Lateral Sclerosis Patients

by
Michael Rentzos
1,
Maria Elepthera Evangelopoulos
1,*,
Eleni Sereti
2,
Vassiliki Zouvelou
1,
Styliani Marmara
2,
Theodoros Alexakis
1 and
Ioannis Evdokimidis
1
1
Department of Neurology, Aeginition Hospital, Athens National University, School of Medicine
2
Immunology Department, Alexandra Hospital, Greece
*
Author to whom correspondence should be addressed.
Neurol. Int. 2013, 5(1), e3; https://doi.org/10.4081/ni.2013.e3
Submission received: 25 June 2012 / Revised: 25 June 2012 / Accepted: 18 October 2012 / Published: 11 February 2013

Abstract

There is evidence that immunological factors may involved in the pathogenetic mecha- nisms of amyotrophic lateral sclerosis (ALS). Few studies to date have explored the status of the humoral immune response in patients with ALS. We examined the presence of humoral immune activation in ALS patients, serum immunoglobulins (IgG, IgA and IgM) levels were measured in 36 patients with ALS and 35 normal controls. Serum IgG, IgM and IgA levels were not significantly different in our ALS patients compared with the control group (P=ns). No correlations of serum IgG, IgM and IgA concentrations with duration, severity of the disease or the clinical form of onset (bulbar or spinal) were found in our ALS patients. Our results do not suggest a humoral immune activation in ALS patients. This does not exclude that immunological mechanisms may be involved in ALS pathogenesis.
Keywords: IgM; IgG; IgA; amyotrophic lateral sclerosis; humoral immune activation IgM; IgG; IgA; amyotrophic lateral sclerosis; humoral immune activation

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MDPI and ACS Style

Rentzos, M.; Evangelopoulos, M.E.; Sereti, E.; Zouvelou, V.; Marmara, S.; Alexakis, T.; Evdokimidis, I. Humoral Immune Activation in Amyotrophic Lateral Sclerosis Patients. Neurol. Int. 2013, 5, e3. https://doi.org/10.4081/ni.2013.e3

AMA Style

Rentzos M, Evangelopoulos ME, Sereti E, Zouvelou V, Marmara S, Alexakis T, Evdokimidis I. Humoral Immune Activation in Amyotrophic Lateral Sclerosis Patients. Neurology International. 2013; 5(1):e3. https://doi.org/10.4081/ni.2013.e3

Chicago/Turabian Style

Rentzos, Michael, Maria Elepthera Evangelopoulos, Eleni Sereti, Vassiliki Zouvelou, Styliani Marmara, Theodoros Alexakis, and Ioannis Evdokimidis. 2013. "Humoral Immune Activation in Amyotrophic Lateral Sclerosis Patients" Neurology International 5, no. 1: e3. https://doi.org/10.4081/ni.2013.e3

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