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Neurology International
Volume 5
Issue 4
10.4081/ni.2013.e20
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Association of the APOE, MTHFR and ACE Genes Polymorphisms and Stroke in Zambian Patients

by
Masharip Atadzhanov
1,*,
Mwila H. Mwaba
1,
Patrice N. Mukomena
1,
Shabir Lakhi
1,
Sruti Rayaprolu
2,
Owen A. Ross
2 and
James F. Meschia
3
1
Department of Internal Medicine, School of Medicine, University of Zambia, Lusaka
2
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
3
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
*
Author to whom correspondence should be addressed.
Neurol. Int. 2013, 5(4), e20; https://doi.org/10.4081/ni.2013.e20
Submission received: 28 January 2013 / Revised: 16 July 2013 / Accepted: 22 July 2013 / Published: 11 November 2013

Abstract

The aim of the present study was to investigate the association of APOE, MTHFR and ACE polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations between the genotype of the APOE, MTHFR and ACE polymorphisms and stroke. The APOE ε2ε4 genotype showed increased risk for hemorrhagic stroke (P<0.05) and also a high risk for ischemic stroke (P=0.05). There was complete absence of the APOE ε2ε2 and the MTHFR TT genotypes in the Zambian population. The difference between cases and controls was not significant for the other genetic variants when analyzed for relationship between stroke, stroke subtype and genotype. We show that genetic variation at the APOE locus affects susceptibility to stroke. No detectable association were observed for the MTHFR and ACE genotypes and stroke in the Zambian population.
Keywords: Sub-Saharan Africa; Zambia; ischemic stroke; intra-cerebral hemorrhage; outcome; risks factors Sub-Saharan Africa; Zambia; ischemic stroke; intra-cerebral hemorrhage; outcome; risks factors

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MDPI and ACS Style

Atadzhanov, M.; Mwaba, M.H.; Mukomena, P.N.; Lakhi, S.; Rayaprolu, S.; Ross, O.A.; Meschia, J.F. Association of the APOE, MTHFR and ACE Genes Polymorphisms and Stroke in Zambian Patients. Neurol. Int. 2013, 5, e20. https://doi.org/10.4081/ni.2013.e20

AMA Style

Atadzhanov M, Mwaba MH, Mukomena PN, Lakhi S, Rayaprolu S, Ross OA, Meschia JF. Association of the APOE, MTHFR and ACE Genes Polymorphisms and Stroke in Zambian Patients. Neurology International. 2013; 5(4):e20. https://doi.org/10.4081/ni.2013.e20

Chicago/Turabian Style

Atadzhanov, Masharip, Mwila H. Mwaba, Patrice N. Mukomena, Shabir Lakhi, Sruti Rayaprolu, Owen A. Ross, and James F. Meschia. 2013. "Association of the APOE, MTHFR and ACE Genes Polymorphisms and Stroke in Zambian Patients" Neurology International 5, no. 4: e20. https://doi.org/10.4081/ni.2013.e20

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