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Gastroenterology Insights
Volume 7
Issue 1
10.4081/gi.2016.6491
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Gastroenterology Insights is published by MDPI from Volume 11 Issue 1 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Pseudomembranous Colitis in a Patient with Lamotrigine-Induced Drug Rash with Eosinophilia and Systemic Symptoms Syndrome

by
Manuel Soria Orozco
1,*,
Eduardo Martín Nares
1,
Alvaro López Iñiguez
1,
Sandra Gónzalez Saldaña
1,
Lorena Valerdi Contreras
1 and
Jair Abdiel Toro Guerrero
2
1
Department of Internal Medicine, Civil Hospital Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
2
Department of Pathology, Civil Hospital Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
*
Author to whom correspondence should be addressed.
Gastroenterol. Insights 2016, 7(1), 6491; https://doi.org/10.4081/gi.2016.6491
Submission received: 2 March 2016 / Revised: 6 May 2016 / Accepted: 11 May 2016 / Published: 19 August 2016

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a hypersensitivity reaction with rash, fever and multiorgan dysfunction potentially lethal in up to 10% of cases. It often affects liver function, but it can also affect kidney, lungs, and heart. Severe gastrointestinal involvement is rare. We present a case of a 31-year-old hispanic woman with pseudomembranous colitis associated with lamotrigine-induced DRESS syndrome. To the best of our knowledge, this is the fourth reported case of severe involvement of the gastrointestinal tract and the first to report pseudomembranous colitis in the setting of DRESS syndrome.
Keywords: DRESS syndrome; multiorgan involvement; pseudomembranous colitis; lamotrigine; anticonvulsant hypersensitivity syndrome DRESS syndrome; multiorgan involvement; pseudomembranous colitis; lamotrigine; anticonvulsant hypersensitivity syndrome

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MDPI and ACS Style

Orozco, M.S.; Martín Nares, E.; López Iñiguez, A.; Gónzalez Saldaña, S.; Valerdi Contreras, L.; Toro Guerrero, J.A. Pseudomembranous Colitis in a Patient with Lamotrigine-Induced Drug Rash with Eosinophilia and Systemic Symptoms Syndrome. Gastroenterol. Insights 2016, 7, 6491. https://doi.org/10.4081/gi.2016.6491

AMA Style

Orozco MS, Martín Nares E, López Iñiguez A, Gónzalez Saldaña S, Valerdi Contreras L, Toro Guerrero JA. Pseudomembranous Colitis in a Patient with Lamotrigine-Induced Drug Rash with Eosinophilia and Systemic Symptoms Syndrome. Gastroenterology Insights. 2016; 7(1):6491. https://doi.org/10.4081/gi.2016.6491

Chicago/Turabian Style

Orozco, Manuel Soria, Eduardo Martín Nares, Alvaro López Iñiguez, Sandra Gónzalez Saldaña, Lorena Valerdi Contreras, and Jair Abdiel Toro Guerrero. 2016. "Pseudomembranous Colitis in a Patient with Lamotrigine-Induced Drug Rash with Eosinophilia and Systemic Symptoms Syndrome" Gastroenterology Insights 7, no. 1: 6491. https://doi.org/10.4081/gi.2016.6491

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