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Case Report

Repeated Spontaneous Clearance of Hepatitis C Virus Infection in the Setting of Long-Term Non-Progression of HIV Infection

by
Genevieve Kerkerian
1,2,
Arshia Alimohammadi
1,*,
Tyler Raycraft
1 and
Brian Conway
1
1
Vancouver Infectious Diseases Center, Canada
2
Department of Medicine, University of British Columbia, Vancouver, Canada
*
Author to whom correspondence should be addressed.
Infect. Dis. Rep. 2017, 9(3), 7142; https://doi.org/10.4081/idr.2017.7142
Submission received: 22 March 2017 / Revised: 7 July 2017 / Accepted: 8 July 2017 / Published: 2 October 2017

Abstract

Hepatitis C Virus (HCV) and human immunodeficiency virus (HIV) are global pandemics that affect 170 million and 35 million individuals, respectively. Up to 45% of individuals infected with HCV clear their infections spontaneously – correlating to factors like aboriginal descent and some host specific immune factors. HIV, however, establishes true latency in infected cells and cannot be cured. In the setting of longterm non-progressors (LTNPs) of HIV, a state of immune preservation and low circulating viral load is established. Regarding HIV/HCV co-infection, little is known about the relationship between spontaneous clearance of HCV infection and long-term control of HIV infection without medical intervention. We describe a case of a HIVinfected female defined as a LTNP in whom spontaneous clearance of HCV was documented on multiple occasions. Similar cases should be documented and identified in an effort to develop novel hypotheses about the natural control of these infections and inform research on immune-based interventions to control them.
Keywords: Hepatitis C; HIV; HCV spontaneous clearance; HIV long-term non-progressor Hepatitis C; HIV; HCV spontaneous clearance; HIV long-term non-progressor

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MDPI and ACS Style

Kerkerian, G.; Alimohammadi, A.; Raycraft, T.; Conway, B. Repeated Spontaneous Clearance of Hepatitis C Virus Infection in the Setting of Long-Term Non-Progression of HIV Infection. Infect. Dis. Rep. 2017, 9, 7142. https://doi.org/10.4081/idr.2017.7142

AMA Style

Kerkerian G, Alimohammadi A, Raycraft T, Conway B. Repeated Spontaneous Clearance of Hepatitis C Virus Infection in the Setting of Long-Term Non-Progression of HIV Infection. Infectious Disease Reports. 2017; 9(3):7142. https://doi.org/10.4081/idr.2017.7142

Chicago/Turabian Style

Kerkerian, Genevieve, Arshia Alimohammadi, Tyler Raycraft, and Brian Conway. 2017. "Repeated Spontaneous Clearance of Hepatitis C Virus Infection in the Setting of Long-Term Non-Progression of HIV Infection" Infectious Disease Reports 9, no. 3: 7142. https://doi.org/10.4081/idr.2017.7142

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