Next Article in Journal
Abdominal Rectus Muscle Pyomyositis: Report of a Case and Review of the Literature
Previous Article in Journal
Repeated Spontaneous Clearance of Hepatitis C Virus Infection in the Setting of Long-Term Non-Progression of HIV Infection
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Infectious Disease Reports
Volume 9
Issue 3
10.4081/idr.2017.7265
idr-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Infectious Disease Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Patterns of Vitamin D, Parathyroid Hormone and c-Terminal Telopeptide of Collagen Type 1 in Caucasian and African Descent HIV-Infected Populations in Central Europe

by
Sebastian Noe
1,*,
Celia Oldenbuettel
1,
Silke Heldwein
1,
Hans Jaeger
1 and
Eva Wolf
2
1
MVZ Karlsplatz, HIV Research and Clinical Care Center, Munich, Germany
2
MUC Research, Munich, Germany
*
Author to whom correspondence should be addressed.
Infect. Dis. Rep. 2017, 9(3), 7265; https://doi.org/10.4081/idr.2017.7265
Submission received: 15 June 2017 / Revised: 4 August 2017 / Accepted: 7 August 2017 / Published: 2 October 2017

Abstract

Risk factors for bone loss in HIV patients might differ or have a different impact in African descent compared to Caucasian populations. The aim of the paper is to analyze the relevance of risk factors on surrogate markers of bone metabolism in HIV-infected African descent and Caucasian patients. This is a cross-sectional study in a single HIV-specialized research and clinical care center in Munich, Germany. We included 889 patients in the study, among them 771 Caucasians (86.7%). Only in Caucasians lower vitamin D levels [OR: 2.5 (95CI: 1.6-3.7)], lower calcium levels [OR: 1.8 (1.2-2.8)], and the use of tenofovir disoproxil fumarate [OR: 2.8 (1.8-4.4)] were significantly associated with elevated PTH in multivariate analysis. Likewise, only in Caucasians elevated PTH was significantly associated with elevated markers of c-terminal telopeptides of collagen type 1 (?-CTX) [OR: 1.7 (1.0-3.0)]. Effects of traditional risk factors for secondary hyperparathyroidism and increased markers of bone turn-over seem to be less distinct in African descent HIV patients. The clinical impact and generalizability of this finding as well as the significance of vitamin D supplementation in African descent patients therefore warrants further investigation.
Keywords: HIV; vitamin D; PTH; African; ?-crosslaps HIV; vitamin D; PTH; African; ?-crosslaps

Share and Cite

MDPI and ACS Style

Noe, S.; Oldenbuettel, C.; Heldwein, S.; Jaeger, H.; Wolf, E. Patterns of Vitamin D, Parathyroid Hormone and c-Terminal Telopeptide of Collagen Type 1 in Caucasian and African Descent HIV-Infected Populations in Central Europe. Infect. Dis. Rep. 2017, 9, 7265. https://doi.org/10.4081/idr.2017.7265

AMA Style

Noe S, Oldenbuettel C, Heldwein S, Jaeger H, Wolf E. Patterns of Vitamin D, Parathyroid Hormone and c-Terminal Telopeptide of Collagen Type 1 in Caucasian and African Descent HIV-Infected Populations in Central Europe. Infectious Disease Reports. 2017; 9(3):7265. https://doi.org/10.4081/idr.2017.7265

Chicago/Turabian Style

Noe, Sebastian, Celia Oldenbuettel, Silke Heldwein, Hans Jaeger, and Eva Wolf. 2017. "Patterns of Vitamin D, Parathyroid Hormone and c-Terminal Telopeptide of Collagen Type 1 in Caucasian and African Descent HIV-Infected Populations in Central Europe" Infectious Disease Reports 9, no. 3: 7265. https://doi.org/10.4081/idr.2017.7265

APA Style

Noe, S., Oldenbuettel, C., Heldwein, S., Jaeger, H., & Wolf, E. (2017). Patterns of Vitamin D, Parathyroid Hormone and c-Terminal Telopeptide of Collagen Type 1 in Caucasian and African Descent HIV-Infected Populations in Central Europe. Infectious Disease Reports, 9(3), 7265. https://doi.org/10.4081/idr.2017.7265

Article Metrics

Back to TopTop