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Microbiology Research
Volume 2
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10.4081/mr.2011.e3
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Article

Efficacy of Linezolid against Staphylococcus aureus in Different Rodent Skin and Soft Tissue Infections Models

by
Madhvi Rao
1,*,
Tarani Kanta Barman
1,*,
Manoj Kumar
1,*,
Tarun Mathur
1,*,
Gunjan Shukla
1,
Ashish Bhati
1,
Krishna Kishore
1,
Tridib Chaira
2,†,
Manisha Pandya
1,* and
Dilip J. Upadhyay
1,*
1
Department of Infectious Diseases, New Drug Discovery Research, Ranbaxy Research Laboratories, Gurgaon, Haryana, India
2
Metabolism and Pharmacokinetics Division, New Drug Discovery Research, Ranbaxy Research Laboratories, Gurgaon, Haryana, India
*
Authors to whom correspondence should be addressed.
†
Drug Metabolism and Pharmaco - kinetics Division, Daiichi Sankyo Research Center in India, Village Sarhaul, Sector 18, Gurgaon, India.
Microbiol. Res. 2011, 2(1), e3; https://doi.org/10.4081/mr.2011.e3
Submission received: 25 May 2011 / Revised: 25 May 2011 / Accepted: 10 June 2011 / Published: 6 July 2011

Abstract

Linezolid is approved for complicated and uncomplicated skin and soft tissue infections. We have evaluated the efficacy of this drug in murine as well as in rat skin and soft tissue infection models using Staphylococcus aureus ATCC and clinical strains. In thigh infection model the dose of linezolid required for more than 1 log10 kill from baseline inoculum in neutropenic mice and rats was 100 mg/kg and 50 mg/Kg, b.i.d/day, respectively, which was 5 and 4 folds more than that in immunocompetent animals, respectively. Dose required to achieve 1 log10 killing was similar against different strains of S. aureus in immunocompetent mouse thigh infection model. However, in murine groin abscess infection model, a dose of 100 mg/kg, b.i.d/day of linezolid produce static effect in 2 days, but revealed to be superior in 4 days treatment and showed approximately 1 log10 killing from base line inoculums. Based upon pharmacokinetic profile, a 24-h AUC/MIC required for linezolid efficacy in murine groin abscess model was 91.5 for the strain used in this study. As linezolid is taken as a gold standard drug in the evaluation of new chemical entity, this data could be useful for comparing the preclinical efficacy of new anti-MRSA agents.
Keywords: murine thigh infection; MRSA; linezolid murine thigh infection; MRSA; linezolid

Share and Cite

MDPI and ACS Style

Rao, M.; Barman, T.K.; Kumar, M.; Mathur, T.; Shukla, G.; Bhati, A.; Kishore, K.; Chaira, T.; Pandya, M.; Upadhyay, D.J. Efficacy of Linezolid against Staphylococcus aureus in Different Rodent Skin and Soft Tissue Infections Models. Microbiol. Res. 2011, 2, e3. https://doi.org/10.4081/mr.2011.e3

AMA Style

Rao M, Barman TK, Kumar M, Mathur T, Shukla G, Bhati A, Kishore K, Chaira T, Pandya M, Upadhyay DJ. Efficacy of Linezolid against Staphylococcus aureus in Different Rodent Skin and Soft Tissue Infections Models. Microbiology Research. 2011; 2(1):e3. https://doi.org/10.4081/mr.2011.e3

Chicago/Turabian Style

Rao, Madhvi, Tarani Kanta Barman, Manoj Kumar, Tarun Mathur, Gunjan Shukla, Ashish Bhati, Krishna Kishore, Tridib Chaira, Manisha Pandya, and Dilip J. Upadhyay. 2011. "Efficacy of Linezolid against Staphylococcus aureus in Different Rodent Skin and Soft Tissue Infections Models" Microbiology Research 2, no. 1: e3. https://doi.org/10.4081/mr.2011.e3

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