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Hematology Reports
Volume 9
Issue 1
10.4081/hr.2017.6986
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Successful Intrathecal Chemotherapy Combined with Radiotherapy Followed by Pomalidomide and Low-Dose Dexamethasone Maintenance Therapy for a Primary Plasma Cell Leukemia Patient

by
Yusuke Yamashita
,
Shinobu Tamura
*,
Takehiro Oiwa
,
Hiroshi Kobata
,
Kodai Kuriyama
,
Toshiki Mushino
,
Shogo Murata
,
Hiroki Hosoi
,
Akinori Nishikawa
,
Nobuyoshi Hanaoka
and
Takashi Sonoki
Department of Hematology/Oncology, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-8509, Japan
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2017, 9(1), 28-31; https://doi.org/10.4081/hr.2017.6986
Submission received: 21 November 2016 / Revised: 3 February 2017 / Accepted: 5 February 2017 / Published: 23 February 2017

Abstract

Primary plasma cell leukemia (PPCL) is a rare aggressive variant of plasma cell disorder and frequently presents with extramedullary disease. Central nervous system (CNS) involvement with PPCL has an extremely poor prognosis. We describe a 46-year-old man with PPCL treated with a combination of lenalidomide, bortezomib, and dexamethasone as induction therapy following upfront allogeneic stem cell transplantation (allo-SCT). Despite achieving a very good partial response, the patient suffered from an isolated CNS relapse 12 months after allo-SCT. He was immediately started on concurrent intrathecal chemotherapy (IT) and cranial irradiation (RT). Subsequently, pomalidomide and low-dose dexamethasone (Pd) were given as maintenance therapy. He has been without CNS recurrence for more than 18 months. Our case suggests that concurrent IT and RT followed by Pd maintenance therapy may be an effective option to control CNS relapse of PPCL after allo-SCT.
Keywords: primary plasma cell leukemia; allogeneic stem cell transplantation; central nervous system relapse; pomalidomide primary plasma cell leukemia; allogeneic stem cell transplantation; central nervous system relapse; pomalidomide

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MDPI and ACS Style

Yamashita, Y.; Tamura, S.; Oiwa, T.; Kobata, H.; Kuriyama, K.; Mushino, T.; Murata, S.; Hosoi, H.; Nishikawa, A.; Hanaoka, N.; et al. Successful Intrathecal Chemotherapy Combined with Radiotherapy Followed by Pomalidomide and Low-Dose Dexamethasone Maintenance Therapy for a Primary Plasma Cell Leukemia Patient. Hematol. Rep. 2017, 9, 28-31. https://doi.org/10.4081/hr.2017.6986

AMA Style

Yamashita Y, Tamura S, Oiwa T, Kobata H, Kuriyama K, Mushino T, Murata S, Hosoi H, Nishikawa A, Hanaoka N, et al. Successful Intrathecal Chemotherapy Combined with Radiotherapy Followed by Pomalidomide and Low-Dose Dexamethasone Maintenance Therapy for a Primary Plasma Cell Leukemia Patient. Hematology Reports. 2017; 9(1):28-31. https://doi.org/10.4081/hr.2017.6986

Chicago/Turabian Style

Yamashita, Yusuke, Shinobu Tamura, Takehiro Oiwa, Hiroshi Kobata, Kodai Kuriyama, Toshiki Mushino, Shogo Murata, Hiroki Hosoi, Akinori Nishikawa, Nobuyoshi Hanaoka, and et al. 2017. "Successful Intrathecal Chemotherapy Combined with Radiotherapy Followed by Pomalidomide and Low-Dose Dexamethasone Maintenance Therapy for a Primary Plasma Cell Leukemia Patient" Hematology Reports 9, no. 1: 28-31. https://doi.org/10.4081/hr.2017.6986

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