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Thalassemia Reports
Volume 4
Issue 2
10.4081/thal.2014.1935
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Thalassemia Reports is published by MDPI from Volume 12 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

γA Gene Repeats Polymorphism for the Analysis of Haplotypes of Abnormal Hemoglobins

by
Nejat Akar
*,
Kadir Sipahi
,
Ece Akar
and
Erkan Yilmaz
Department of Pediatric Molecular Genetics, Ankara University, Ankara, Turkey
*
Author to whom correspondence should be addressed.
Thalass. Rep. 2014, 4(2), 1935; https://doi.org/10.4081/thal.2014.1935
Submission received: 20 September 2013 / Revised: 14 January 2014 / Accepted: 11 February 2014 / Published: 29 September 2014

Abstract

Aim of this study was to analyze γ A gene repeat polymorphism for the analysis of haplotypes of hemoglobin (Hb) variants such as Hb S, Hb D-Punjab, Hb O-Arab. Sickle cell cases had mainly Benin and Arab/Indian haplotype. We found three different haplotypes among Hb S, Hb O Arab and Hb D-Punjab cases. We named these three variants as Anatolian-1 and Anatolian-2 and Asian. Our data revealed that Hb O Arab may arise twice one from Asia and the other from Europe.
Keywords: hemoglobin; sickle cell disease; hemoglobin D-Punjab; repetitive sequence; Hb OArab; haplotype hemoglobin; sickle cell disease; hemoglobin D-Punjab; repetitive sequence; Hb OArab; haplotype

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MDPI and ACS Style

Akar, N.; Sipahi, K.; Akar, E.; Yilmaz, E. γA Gene Repeats Polymorphism for the Analysis of Haplotypes of Abnormal Hemoglobins. Thalass. Rep. 2014, 4, 1935. https://doi.org/10.4081/thal.2014.1935

AMA Style

Akar N, Sipahi K, Akar E, Yilmaz E. γA Gene Repeats Polymorphism for the Analysis of Haplotypes of Abnormal Hemoglobins. Thalassemia Reports. 2014; 4(2):1935. https://doi.org/10.4081/thal.2014.1935

Chicago/Turabian Style

Akar, Nejat, Kadir Sipahi, Ece Akar, and Erkan Yilmaz. 2014. "γA Gene Repeats Polymorphism for the Analysis of Haplotypes of Abnormal Hemoglobins" Thalassemia Reports 4, no. 2: 1935. https://doi.org/10.4081/thal.2014.1935

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