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10.3390/jcm12020621
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Article

Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology

by
Roberto Cemin
1,*,
Simona Casablanca
1,
Luisa Foco
2,
Elisabeth Schoepf
1,
Andrea Erlicher
1,
Renato Di Gaetano
1 and
Davide Ermacora
1
1
Division of Cardiology, San Maurizio Regional Hospital, 39100 Bolzano, Italy
2
Eurac Research, Institute for Biomedicine, University of Lübeck, 39100 Bolzano, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(2), 621; https://doi.org/10.3390/jcm12020621
Submission received: 11 December 2022 / Revised: 4 January 2023 / Accepted: 8 January 2023 / Published: 12 January 2023
(This article belongs to the Section Cardiovascular Medicine)
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Abstract

Sacubitril/valsartan (SV) has been demonstrated to reduce cardiovascular mortality, hospitalization for heart failure and to induce reverse ventricular remodeling. The present study was designed to confirm the effects of SV in a selected population of patients with HFrEF and to evaluate the different responses between patients with an ischemic or a non-ischemic etiology. A total of 79 patients with indication of SV were recruited prospectively during a timelapse of 4 years. SV was overall associated to a reduction of end-diastolic and end-systolic volume, of NT-proBNP levels, furosemide dosage and NYHA functional class, together with an increase in EF. These changes were more evident in patients with non-ischemic dilated cardiomyopathy, who showed a significant improvement in ventricular volumes, ejection fraction, TAPSE and blood levels of NT-proBNP. Kaplan–Meier curves confirmed a greater benefit in terms of ejection-fraction improvement in non-ischemic patients compared to the ischemic group. The results of the present study confirm the positive effect of SV on NYHA functional class, NT- proBNP, left ventricular volumes and EF in HFrEF patients, showing evidence of association of SV with ventricular remodeling in patients with dilated cardiomyopathy of non-ischemic etiology compared to the ischemic group.
Keywords: chronic heart failure; ventricular function; sacubitril/valsartan chronic heart failure; ventricular function; sacubitril/valsartan

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MDPI and ACS Style

Cemin, R.; Casablanca, S.; Foco, L.; Schoepf, E.; Erlicher, A.; Di Gaetano, R.; Ermacora, D. Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology. J. Clin. Med. 2023, 12, 621. https://doi.org/10.3390/jcm12020621

AMA Style

Cemin R, Casablanca S, Foco L, Schoepf E, Erlicher A, Di Gaetano R, Ermacora D. Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology. Journal of Clinical Medicine. 2023; 12(2):621. https://doi.org/10.3390/jcm12020621

Chicago/Turabian Style

Cemin, Roberto, Simona Casablanca, Luisa Foco, Elisabeth Schoepf, Andrea Erlicher, Renato Di Gaetano, and Davide Ermacora. 2023. "Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology" Journal of Clinical Medicine 12, no. 2: 621. https://doi.org/10.3390/jcm12020621

APA Style

Cemin, R., Casablanca, S., Foco, L., Schoepf, E., Erlicher, A., Di Gaetano, R., & Ermacora, D. (2023). Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology. Journal of Clinical Medicine, 12(2), 621. https://doi.org/10.3390/jcm12020621

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