Next Article in Journal
A Novel UC Exclusion Diet and Antibiotics for Treatment of Mild to Moderate Pediatric Ulcerative Colitis: A Prospective Open-Label Pilot Study
Previous Article in Journal
Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
Previous Article in Special Issue
The Functional DNA Methylation Signatures Relevant to Altered Immune Response of Neonatal T Cells with l-Arginine Supplementation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 13
Issue 11
10.3390/nu13113735
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring

by
Saida Breuer
1,
Philipp Kasper
2,
Christina Vohlen
1,
Ruth Janoschek
1,
Thorben Hoffmann
1,
Sarah Appel
1,
Elena Müller-Limberger
1,
Andrea Mesaros
3,
Stefan Rose-John
4,
Christoph Garbers
5,
Stefan Müller
6,
Jan-Wilm Lackmann
7,
Esther Mahabir
8,
Jörg Dötsch
1,
Eva Hucklenbruch-Rother
1,† and
Inga Bae-Gartz
1,*,†
1
Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, D-50937 Cologne, Germany
2
Clinic for Gastroenterology and Hepatology, Faculty of Medicine and University Hospital Cologne, University of Cologne, D-50937 Cologne, Germany
3
Department of Phenotyping, Max-Planck Institute for Biology of Aging, University of Cologne, D-50931 Cologne, Germany
4
Department for Biochemistry, Christian-Albrechts-University zu Kiel, D-24098 Kiel, Germany
5
Department of Pathology, Medical Faculty, Otto-von-Guericke-University Magdeburg, D-39120 Magdeburg, Germany
6
Center for Molecular Medicine (CMMC), Proteomics Facility, University of Cologne, D-50931 Cologne, Germany
7
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, D-50931 Cologne, Germany
8
Comparative Medicine, Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, D-50937 Cologne, Germany
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2021, 13(11), 3735; https://doi.org/10.3390/nu13113735
Submission received: 1 September 2021 / Revised: 18 October 2021 / Accepted: 21 October 2021 / Published: 23 October 2021
(This article belongs to the Special Issue Newborn Nutrition)
Browse Figures
Versions Notes

Abstract

Maternal obesity greatly affects next generations, elevating obesity risk in the offspring through perinatal programming and flawed maternal and newborn nutrition. The exact underlying mechanisms are poorly understood. Interleukin-6 (IL-6) mediates its effects through a membrane-bound receptor or by trans-signaling (tS), which can be inhibited by the soluble form of the co-receptor gp130 (sgp130). As IL-6 tS mediates western-style diet (WSD) effects via chronic low-grade inflammation (LGI) and LGI is an important mediator in brain–adipose tissue communication, this study aims at determining the effects of maternal obesity in a transgenic mouse model of brain-restricted IL-6tS inhibition (GFAPsgp130) on offspring’s short- and long-term body composition and epigonadal white adipose tissue (egWAT) metabolism. Female wild type (WT) or transgenic mice were fed either standard diet (SD) or WSD pregestationally, during gestation, and lactation. Male offspring received SD from postnatal day (P)21 to P56 and were metabolically challenged with WSD from P56 to P120. At P21, offspring from WT and transgenic dams that were fed WSD displayed increased body weight and egWAT mass, while glucose tolerance testing showed the strongest impairment in GFAPsgp130WSD offspring. Simultaneously, egWAT proteome reveals a characteristic egWAT expression pattern in offspring as a result of maternal conditions. IL-6tS inhibition in transgenic mice was in tendency associated with lower body weight in dams on SD and their respective offspring but blunted by the WSD. In conclusion, maternal nutrition affects offspring’s body weight and egWAT metabolism predominantly independent of IL-6tS inhibition, emphasizing the importance of maternal and newborn nutrition for long-term offspring health.
Keywords: perinatal programming; maternal nutrition; newborn nutrition; IL-6-trans-signaling; hypothalamic dysfunction; prevention; western-style-diet; GFAP (glial fibrillary acidic protein); sgp130 (soluble gp130); proteomics perinatal programming; maternal nutrition; newborn nutrition; IL-6-trans-signaling; hypothalamic dysfunction; prevention; western-style-diet; GFAP (glial fibrillary acidic protein); sgp130 (soluble gp130); proteomics

Share and Cite

MDPI and ACS Style

Breuer, S.; Kasper, P.; Vohlen, C.; Janoschek, R.; Hoffmann, T.; Appel, S.; Müller-Limberger, E.; Mesaros, A.; Rose-John, S.; Garbers, C.; et al. Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring. Nutrients 2021, 13, 3735. https://doi.org/10.3390/nu13113735

AMA Style

Breuer S, Kasper P, Vohlen C, Janoschek R, Hoffmann T, Appel S, Müller-Limberger E, Mesaros A, Rose-John S, Garbers C, et al. Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring. Nutrients. 2021; 13(11):3735. https://doi.org/10.3390/nu13113735

Chicago/Turabian Style

Breuer, Saida, Philipp Kasper, Christina Vohlen, Ruth Janoschek, Thorben Hoffmann, Sarah Appel, Elena Müller-Limberger, Andrea Mesaros, Stefan Rose-John, Christoph Garbers, and et al. 2021. "Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring" Nutrients 13, no. 11: 3735. https://doi.org/10.3390/nu13113735

APA Style

Breuer, S., Kasper, P., Vohlen, C., Janoschek, R., Hoffmann, T., Appel, S., Müller-Limberger, E., Mesaros, A., Rose-John, S., Garbers, C., Müller, S., Lackmann, J.-W., Mahabir, E., Dötsch, J., Hucklenbruch-Rother, E., & Bae-Gartz, I. (2021). Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring. Nutrients, 13(11), 3735. https://doi.org/10.3390/nu13113735

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop