Characterizing Micronutrient Status and Risk Factors among Late Adolescent and Young Women in Rural Pakistan: A Cross-Sectional Assessment of the MaPPS Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Conceptual Framework
2.2. Study Participants
2.3. Data Collection
2.4. Lab Methods
2.5. Categorization of Nutritional Status (Dependent Variables)
2.6. SDoH (Explanatory Variables)
2.7. Statistical Analysis
2.8. Ethics Approval
3. Results
3.1. Participant Characteristics
3.2. Nutritional Status Characteristics
3.3. SDoH and Micronutrient Status Hierarchical Model Generation
3.3.1. Hb Concentration
3.3.2. IDA
3.3.3. Vitamin A Deficiency
3.3.4. Vitamin D Deficiency
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristic | All Participants | Micronutrient Status Subgroup | p-Value |
---|---|---|---|
Age (years), mean ± SD | 18.8 ± 2.3 | 17.2 ± 1.2 | <0.001 |
Highest level of education completed, n (%) | |||
None | 11,384 (44.7) | 1615 (46.7) | <0.001 |
Primary | 6063 (23.8) | 842 (24.3) | |
Secondary or higher | 8000 (31.5) | 1004 (29.0) | |
Employed outside the home, n (%) | 9620 (38.1) | 1391 (40.2) | <0.001 |
Muslim, n (%) | 23,045 (90.6) | 3116 (90.0) | <0.001 |
Wealth quintile, n (%) | |||
Poorest | 4549 (17.9) | 680 (19.6) | <0.001 |
Poor | 4853 (19.1) | 734 (21.2) | |
Middle | 5139 (20.2) | 769 (22.2) | |
Rich | 5360 (21.1) | 726 (21.0) | |
Richest | 5546 (21.8) | 552 (15.9) | |
Currently married 1, n (%) | 5685 (22.3) | 400 (11.6) | <0.001 |
Age when married husband (years), mean ± SD | 16.9 ± 1.8 | 15.8 ± 1.1 | <0.001 |
Has been pregnant 2, n (%) | 3478 (13.7) | 194 (5.6) | <0.001 |
Age at first pregnancy 2, mean ± SD | 17.5 ± 1.6 | 16.5 ± 1.2 | <0.001 |
Characteristic | All Participants | Micronutrient Status Subgroup | p-Value |
---|---|---|---|
BMI categorization, n (%) | |||
Underweight (<18.5 kg/m2) | 9396 (36.9) | 1452 (42.0) | <0.001 |
Normal (18.5–24.9 kg/m2) | 13,463 (52.9) | 1770 (51.1) | |
Overweight (25–29.9 kg/m2) | 2011 (7.9) | 203 (5.9) | |
Obese (≥30 kg/m2) | 577 (2.3) | 36 (1.0) | |
Stunted (<145 cm), n (%) | 2345 (9.2) | 358 (10.3) | 0.04 |
Food insecure, n (%) | 6355 (25.0) | 1052 (30.4) | <0.001 |
Hb concentration 1 (g/dL), mean ± SD | 11.5 ± 2.0 | 11.8 ± 1.9 | <0.001 |
Anemia status 1, n (%) | |||
Mild (11.9–11.0 g/dL) | 5497 (21.6) | 735 (21.2) | <0.001 |
Moderate (10.9–8.0 g/dL) | 6798 (26.7) | 752 (21.7) | |
Severe (<8.0 g/dL) | 1353 (5.3) | 162 (4.7) | |
Serum ferritin concentration 2 (µg/L), geometric mean (95% CI) | - | 10.4 (10.1 to 10.8) | - |
Iron deficiency 3, n (%) | - | 2264 (65.9) | - |
Iron deficiency anemia 4, n (%) | - | 1307 (38.0) | - |
Serum retinol concentration 6 (µmol/L), mean ± SD | - | 0.96 ± 0.49 | - |
Vitamin A deficiency 5, n (%) | - | 1092 (31.8) | - |
Serum 25(OH)D concentration 5 (ng/mL), mean ± SD | - | 14.9 ± 7.9 | - |
Vitamin D deficiency 6, n (%) | - | 2777 (81.1) | - |
Number of deficiencies 7, mean ± SD | 1.5 ± 0.8 | ||
CRP concentration, (mg/L), mean ± SD | - | 1.42 ± 3.78 | - |
Acute inflammation 8, n (%) | - | 171 (4.9) | - |
SDoH | n (%) | Hb Concentration (g/dL) Mean (95% CI) | Crude Analysis | Multivariable Adjusted Analysis | ||
---|---|---|---|---|---|---|
β-Coefficient (95% CI) | p-Value | β-Coefficient (95% CI) | p-Value | |||
Level 1: Socioeconomic status | ||||||
Highest level of education | <0.001 | <0.001 | ||||
None | 11,382 (44.7) | 11.3 (11.3 to 11.4) | (reference) | (reference) | ||
Primary | 6062 (23.8) | 11.6 (11.5 to 11.6) | 0.26 (0.20 to 0.32) | 0.14 (0.08 to 0.20) | ||
Secondary or higher | 7999 (31.4) | 11.8 (11.8 to 11.9) | 0.50 (0.44 to 0.55) | 0.28 (0.21 to 0.35) | ||
Occupation | <0.001 | <0.001 | ||||
Unskilled manual labor | 4458 (17.5) | 11.2 (11.1 to 11.2) | (reference) | (reference) | ||
Skilled manual labor | 5133 (20.2) | 11.7 (11.6 to 11.7) | 0.48 (0.41 to 0.56) | 0.23 (0.15 to 0.32) | ||
Within the home | 12,129 (47.7) | 11.5 (11.5 to 11.6) | 0.37 (0.31 to 0.44) | 0.14 (0.07 to 0.21) | ||
Other | 3723 (14.6) | 11.8 (11.7 to 11.8) | 0.62 (0.53 to 0.70) | 0.12 (0.01 to 0.22) | ||
Religion | <0.001 | - | ||||
Hindu | 2401 (9.4) | 11.4 (11.3 to 11.4) | (reference) | - | ||
Muslim | 23,042 (90.6) | 11.6 (11.5 to 11.6) | 0.19 (0.11 to 0.27) | - | ||
Wealth quintile | <0.001 | <0.001 | ||||
Poorest | 4548 (17.9) | 11.2 (11.2 to 11.3) | (reference) | (reference) | ||
Poor | 4853 (19.1) | 11.4 (11.3 to 11.4) | 0.11 (0.04 to 0.19) | 0.03 (−0.05 to 0.11) | ||
Middle | 5138 (20.2) | 11.5 (11.4 to 11.6) | 0.25 (0.18 to 0.33) | 0.13 (0.05 to 0.21) | ||
Rich | 5360 (21.1) | 11.7 (11.6 to 11.7) | 0.41 (0.33 to 0.48) | 0.22 (0.14 to 0.30) | ||
Richest | 5544 (21.8) | 11.8 (11.8 to 11.9) | 0.60 (0.53 to 0.68) | 0.34 (0.24 to 0.43) | ||
Level 2: Household and personal characteristics | ||||||
Marital status | 0.72 | - | ||||
Married | 5685 (22.3) | 11.3 (11.3 to 11.4) | (reference) | - | ||
Unmarried | 19,758 (77.7) | 11.6 (11.6 to 11.6) | −0.01 (−0.07 to 0.05) | - | ||
Has been pregnant | 0.05 | <0.001 | ||||
Yes | 3478 (13.7) | 11.5 (11.5 to 11.6) | (reference) | (reference) | ||
No | 21,965 (86.3) | 11.5 (11.5 to 11.6) | −0.07 (−0.14 to 0) | −0.15 (−0.22 to −0.08) | ||
Household food security status | <0.001 | - | ||||
Food insecure | 6354 (25.0) | 11.6 (11.5 to 11.7) | (reference) | - | ||
Food secure | 19,089 (75.0) | 11.5 (11.5 to 11.6) | 0.30 (0.24 to 0.35) | - | ||
Level 3: Health and well-being characteristics | ||||||
Perception of own health | <0.001 | 0.001 | ||||
Poor or fair | 2808 (11.0) | 11.3 (11.3 to 11.4) | (reference) | (reference) | ||
Good | 16,556 (65.1) | 11.5 (11.5 to 11.6) | 0.21 (0.13 to 0.29) | 0.14 (0.06 to 0.21) | ||
Excellent | 6079 (23.9) | 11.6 (11.6 to 11.7) | 0.28 (0.19 to 0.36) | 0.17 (0.08 to 0.25) | ||
Experience of depression-like feelings | 0.002 | - | ||||
Severe or extremely severe | 1223 (4.8) | 11.5 (11.4 to 11.6) | (reference) | - | ||
Moderate | 2652 (10.4) | 11.4 (11.4 to 11.5) | −0.06 (−0.19 to 0.07) | - | ||
Mild | 2158 (8.5) | 11.5 (11.4 to 11.5) | −0.03 (−0.16 to 0.10) | - | ||
None | 19,410 (76.3) | 11.6 (11.5 to 11.6) | 0.07 (−0.04 to 0.18) | - | ||
Experience of anxiety-like feelings | 0.002 | - | ||||
Severe or extremely severe | 3313 (13.0) | 11.5 (11.4 to 11.5) | (reference) | - | ||
Moderate | 3637 (14.3) | 11.5 (11.4 to 11.5) | 0.02 (−0.07 to 0.11) | - | ||
Mild | 1684 (6.6) | 11.5 (11.4 to 11.6) | 0.07 (−0.04 to 0.19) | - | ||
None | 16,809 (66.1) | 11.6 (11.5 to 11.6) | 0.11 (0.04 to 0.19) | - | ||
Experience of stress-like feelings | 0.55 | - | ||||
Severe or extremely severe | 895 (3.5) | 11.5 (11.4 to 11.7) | (reference) | - | ||
Moderate | 1356 (5.3) | 11.5 (11.4 to 11.6) | −0.05 (−0.21 to 0.11) | - | ||
Mild | 1506 (5.9) | 11.5 (11.4 to 11.6) | −0.04 (−0.20 to 0.12) | - | ||
None | 21,686 (85.2) | 11.5 (11.5 to 11.6) | 0.01 (−0.12 to 0.14) | - | ||
Level 4: Actions and practices-related characteristics | ||||||
Self-efficacy | <0.001 | - | ||||
Low | 8630 (33.9) | 11.4 (11.4 to 11.5) | (reference) | - | ||
Moderate | 12,868 (50.6) | 11.6 (11.5 to 11.6) | 0.16 (0.11 to 0.21) | - | ||
High | 3945 (15.5) | 11.6 (11.6 to 11.7) | 0.22 (0.15 to 0.29) | - | ||
Decision-making autonomy | 0.002 | - | ||||
All decisions made by family | 12,606 (49.5) | 11.5 (11.5 to 11.5) | (reference) | - | ||
Most decisions made by family | 8332 (32.7) | 11.6 (11.5 to 11.6) | 0.06 (0.003 to 0.11) | - | ||
Jointly made with family or autonomously | 4505 (17.7) | 11.6 (11.6 to 11.7) | 0.11 (0.05 to 0.18) | - | ||
Skipping breakfast | 0.09 | - | ||||
Skips breakfast | 7608 (29.9) | 11.5 (11.5 to 11.5) | (reference) | - | ||
Eats breakfast | 17,835 (70.1) | 11.5 (11.5 to 11.6) | 0.04 (−0.01 to 0.10) | - | ||
Eating dinner with family | 0.68 | - | ||||
Never | 6820 (26.8) | 11.6 (11.5 to 11.6) | (reference) | - | ||
Sometimes | 3489 (13.7) | 11.5 (11.5 to 11.6) | −0.03 (−0.11 to 0.05) | - | ||
Everyday | 15,134 (59.5) | 11.5 (11.5 to 11.6) | −0.02 (−0.07 to 0.03) | - |
SDoH | IDA (n = 3438) | Vitamin A Deficiency (n = 3437) | Vitamin D Deficiency (n = 3423) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Crude | Multivariable Adjusted | Crude | Multivariable Adjusted | Crude | Multivariable Adjusted | |||||||
OR (95% CI) | p-Value | OR (95% CI) | p-Value | OR (95% CI) | p-Value | OR (95% CI) | p-Value | OR (95% CI) | p-Value | OR (95% CI) | p-Value | |
Level 1: Structural factors—socioeconomic status | ||||||||||||
Highest level of education | ||||||||||||
None | (base) | - | (base) | - | (base) | - | - | - | (base) | - | (base) | - |
Primary | 0.82 (0.69 to 0.98) | 0.03 | 0.82 (0.71 to 0.96) | 0.01 | 0.85 (0.71 to 1.02) | 0.08 | - | - | 1.43 (1.16 to 1.77) | 0.001 | 1.28 (0.97 to 1.71) | 0.08 |
Secondary or higher | 0.74 (0.63 to 0.87) | <0.001 | 0.74 (0.63 to 0.87) | <0.001 | 0.93 (0.79 to 1.10) | 0.42 | - | - | 2.19 (1.75 to 2.73) | <0.001 | 1.67 (1.17 to 2.38) | 0.01 |
Occupation | ||||||||||||
Unskilled manual labor | (base) | - | - | - | (base) | - | - | - | (base) | - | (base) | - |
Skilled manual labor | 0.87 (0.70 to 1.08) | 0.22 | - | - | 1.01 (0.81 to 1.27) | 0.91 | - | - | 2.78 (2.11 to 3.67) | <0.001 | 2.56 (1.70 to 3.87) | <0.001 |
Within the home | 0.88 (0.73 to 1.05) | 0.16 | - | - | 1.07 (0.88 to 1.29) | 0.50 | - | - | 1.93 (1.57 to 2.37) | <0.001 | 1.74 (1.40 to 2.16) | <0.001 |
Other | 0.74 (0.59 to 0.93) | 0.01 | - | - | 1.08 (0.85 to 1.38) | 0.51 | - | - | 3.34 (2.46 to 4.54) | <0.001 | 2.19 (1.49 to 3.24) | <0.001 |
Religion | ||||||||||||
Hindu | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Muslim | 0.98 (0.78 to 1.23) | 0.85 | - | - | 1.31 (1.02 to 1.68) | 0.04 | - | - | 1.79 (1.39 to 2.3) | <0.001 | - | - |
Wealth quintile | ||||||||||||
Poorest | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Poor | 1.02 (0.82 to 1.26) | 0.86 | - | - | 0.92 (0.73 to 1.15) | 0.46 | - | - | 0.93 (0.73 to 1.20) | 0.59 | - | - |
Middle | 0.97 (0.79 to 1.20) | 0.79 | - | - | 0.94 (0.75 to 1.18) | 0.60 | - | - | 1.20 (0.93 to 1.56) | 0.16 | - | - |
Rich | 1.11 (0.89 to 1.37) | 0.36 | - | - | 1.32 (1.06 to 1.65) | 0.01 | - | - | 1.55 (1.18 to 2.04) | 0.002 | - | - |
Richest | 0.76 (0.60 to 0.96) | 0.02 | - | - | 1.10 (0.86 to 1.40) | 0.44 | - | - | 1.61 (1.19 to 2.17) | 0.002 | - | - |
Level 2: Intermediary factors—household and personal characteristics | ||||||||||||
Marital status | ||||||||||||
Married | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Unmarried | 1.04 (0.84 to 1.29) | 0.73 | - | - | 1.24 (0.98 to 1.56) | 0.075 | - | - | 1.46 (1.22 to 1.75) | <0.001 | - | - |
Has been pregnant | ||||||||||||
Yes | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
No | 1.07 (0.79 to 1.45) | 0.65 | - | - | 1.24 (0.90 to 1.72) | 0.19 | - | - | 1.12 (0.86 to 1.45) | 0.41 | - | - |
Household food security status | ||||||||||||
Food insecure | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Food secure | 0.88 (0.76 to 1.02) | 0.09 | - | - | 1.18 (1.01 to 1.38) | 0.04 | - | - | 1.13 (0.79 to 1.62) | 0.50 | - | - |
Level 3: Intermediary factors—health and well-being characteristics | ||||||||||||
Perception of own health | ||||||||||||
Poor or fair | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Good | 0.81 (0.66 to 1.00) | 0.05 | - | - | 1.14 (0.91 to 1.43) | 0.25 | - | - | 1.56 (1.22 to 1.98) | <0.001 | 0.43 (0.16 to 0.71) | 0.002 |
Excellent | 0.87 (0.69 to 1.10) | 0.25 | - | - | 1.27 (0.99 to 1.64) | 0.06 | - | - | 1.50 (1.13 to 1.98) | 0.004 | 0.32 (0 to 0.63) | 0.05 |
Experience of depression-like feelings | ||||||||||||
Severe or extremely severe | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Moderate | 1.06 (0.72 to 1.55) | 0.77 | - | - | 1.92 (1.27 to 2.91) | 0.002 | - | - | 0.96 (0.61 to 1.54) | 0.88 | - | - |
Mild | 0.93 (0.63 to 1.37) | 0.71 | - | - | 1.55 (1.01 to 2.38) | 0.04 | - | - | 0.81 (0.51 to 1.28) | 0.36 | - | - |
None | 0.96 (0.69 to 1.34) | 0.82 | - | - | 1.35 (0.93 to 1.96) | 0.11 | - | - | 1.12 (0.75 to 1.68) | 0.58 | - | - |
Experience of anxiety-like feelings | ||||||||||||
Severe or extremely severe | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Moderate | 0.97 (0.75 to 1.25) | 0.80 | - | - | 1.11 (0.85 to 1.45) | 0.44 | - | - | 0.72 (0.53 to 0.98) | 0.04 | - | - |
Mild | 1.05 (0.76 to 1.44) | 0.76 | - | - | 0.92 (0.66 to 1.29) | 0.63 | - | - | 1.14 (0.76 to 1.73) | 0.53 | - | - |
None | 0.95 (0.77 to 1.18) | 0.64 | - | - | 1.00 (0.80 to 1.25) | 0.98 | - | - | 1.01 (0.77 to 1.32) | 0.95 | - | - |
Experience of stress-like feelings | ||||||||||||
Severe or extremely severe | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Moderate | 1.06 (0.64 to 1.73) | 0.83 | - | - | 0.96 (0.57 to 1.62) | 0.89 | - | - | 2.55 (1.36 to 4.8) | 0.004 | - | - |
Mild | 1.11 (0.69 to 1.80) | 0.67 | - | - | 0.94 (0.57 to 1.56) | 0.81 | - | - | 1.45 (0.83 to 2.53) | 0.19 | - | - |
None | 1.11 (0.75 to 1.65) | 0.60 | - | - | 1.10 (0.73 to 1.66) | 0.64 | - | - | 1.39 (0.90 to 2.16) | 0.14 | - | - |
Level 4: Intermediary factors—actions and practices-related characteristics | ||||||||||||
Self-efficacy | ||||||||||||
Low | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Moderate | 0.86 (0.74 to 1.00) | 0.06 | - | - | 1.11 (0.94 to 1.30) | 0.21 | - | - | 1.21 (1.00 to 1.46) | 0.05 | - | - |
High | 0.84 (0.69 to 1.03) | 0.09 | - | - | 0.84 (0.67 to 1.04) | 0.11 | - | - | 1.10 (0.86 to 1.40) | 0.47 | - | - |
Decision-making autonomy | ||||||||||||
All decisions made by family | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Most decisions made by family | 0.85 (0.73 to 0.99) | 0.03 | - | - | 1.22 (1.05 to 1.43) | 0.01 | - | - | 1.08 (0.89 to 1.31) | 0.44 | - | - |
Jointly made with family or autonomously | 0.84 (0.68 to 1.03) | 0.10 | - | - | 0.98 (0.78 to 1.22) | 0.85 | - | - | 0.76 (0.59 to 0.97) | 0.04 | - | - |
Skipping breakfast | ||||||||||||
Skips breakfast | (base) | - | - | - | (base) | - | - | - | (base) | - | - | - |
Eats breakfast | 1.00 (0.86 to 1.16) | 0.97 | - | - | 0.95 (0.81 to 1.11) | 0.50 | - | - | 1.11 (0.92 to 1.33) | 0.29 | - | - |
Eating dinner with family | ||||||||||||
Never | (base) | - | - | (base) | - | - | - | (base) | - | - | ||
Sometimes | 1.17 (0.92 to 1.50) | 0.20 | - | - | 0.75 (0.57 to 0.98) | 0.04 | - | - | 0.76 (0.57 to 1.02) | 0.07 | - | - |
Everyday | 1.09 (0.93 to 1.29) | 0.29 | - | - | 1.18 (0.99 to 1.39) | 0.06 | - | - | 1.02 (0.83 to 1.25) | 0.83 | - | - |
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Baxter, J.-A.B.; Wasan, Y.; Hussain, A.; Soofi, S.B.; Ahmed, I.; Bhutta, Z.A. Characterizing Micronutrient Status and Risk Factors among Late Adolescent and Young Women in Rural Pakistan: A Cross-Sectional Assessment of the MaPPS Trial. Nutrients 2021, 13, 1237. https://doi.org/10.3390/nu13041237
Baxter J-AB, Wasan Y, Hussain A, Soofi SB, Ahmed I, Bhutta ZA. Characterizing Micronutrient Status and Risk Factors among Late Adolescent and Young Women in Rural Pakistan: A Cross-Sectional Assessment of the MaPPS Trial. Nutrients. 2021; 13(4):1237. https://doi.org/10.3390/nu13041237
Chicago/Turabian StyleBaxter, Jo-Anna B., Yaqub Wasan, Amjad Hussain, Sajid B. Soofi, Imran Ahmed, and Zulfiqar A. Bhutta. 2021. "Characterizing Micronutrient Status and Risk Factors among Late Adolescent and Young Women in Rural Pakistan: A Cross-Sectional Assessment of the MaPPS Trial" Nutrients 13, no. 4: 1237. https://doi.org/10.3390/nu13041237