Next Article in Journal
The Administration of Panax Ginseng Berry Extract Attenuates High-Fat-Diet-Induced Sarcopenic Obesity in C57BL/6 Mice
Previous Article in Journal
Food Sales and Adult Weight Status: Results of a Cross-Sectional Study in England
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 14
Issue 9
10.3390/nu14091746
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Investigation of Behavior and Plasma Levels of Corticosterone in Restrictive- and Ad Libitum-Fed Diet-Induced Obese Mice

by
Martin Allweyer
,
Matthias Emde
,
Ina Bähr
,
Julia Spielmann
,
Philipp Bieramperl
,
Wiebke Naujoks
and
Heike Kielstein
*
Institute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06108 Halle, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2022, 14(9), 1746; https://doi.org/10.3390/nu14091746
Submission received: 7 March 2022 / Revised: 15 April 2022 / Accepted: 19 April 2022 / Published: 22 April 2022
(This article belongs to the Section Nutrition and Obesity)
Browse Figures
Versions Notes

Abstract

Diet-induced obesity (DIO) mice models are commonly used to investigate obesity-related health problems. Until now, only sparse data exist on the influence of DIO on behavior and stress hormones in mice. The present study investigates high-fat DIO with two different feeding regimes on behavioral parameters in mice. Various behavioral tests (open field, elevated plus maze, social interaction, hotplate) were performed with female BALB/c and male C57BL/6 mice after a feeding period of twelve weeks (restrictive vs. ad libitum and normal-fat diet vs. high-fat diet) to investigate levels of anxiety and aggression. BALB/c mice were DIO-resistant and therefore the prerequisite for the behavior analyses was not attained. C57BL/6 mice fed a high-fat diet had a significantly higher body weight and fat mass compared to C57BL/6 mice fed a control diet. Interestingly, the DIO C57BL/6 mice showed no changes in their aggression- or anxiety-related behavior but showed a significant change in the anxiety index. This was probably due to a lower activity level, as other ethological parameters did not show an altered anxiety-related behavior. In the ad libitum-fed DIO group, the highest corticosterone level was detected. Changes due to the feeding regime (restrictive vs. ad libitum) were not observed. These results provide a possible hint to a bias in the investigation of DIO-related health problems in laboratory animal experiments, which may be influenced by the lower activity level.
Keywords: obesity; behavior; mice; activity; anxiety; aggression obesity; behavior; mice; activity; anxiety; aggression

Share and Cite

MDPI and ACS Style

Allweyer, M.; Emde, M.; Bähr, I.; Spielmann, J.; Bieramperl, P.; Naujoks, W.; Kielstein, H. Investigation of Behavior and Plasma Levels of Corticosterone in Restrictive- and Ad Libitum-Fed Diet-Induced Obese Mice. Nutrients 2022, 14, 1746. https://doi.org/10.3390/nu14091746

AMA Style

Allweyer M, Emde M, Bähr I, Spielmann J, Bieramperl P, Naujoks W, Kielstein H. Investigation of Behavior and Plasma Levels of Corticosterone in Restrictive- and Ad Libitum-Fed Diet-Induced Obese Mice. Nutrients. 2022; 14(9):1746. https://doi.org/10.3390/nu14091746

Chicago/Turabian Style

Allweyer, Martin, Matthias Emde, Ina Bähr, Julia Spielmann, Philipp Bieramperl, Wiebke Naujoks, and Heike Kielstein. 2022. "Investigation of Behavior and Plasma Levels of Corticosterone in Restrictive- and Ad Libitum-Fed Diet-Induced Obese Mice" Nutrients 14, no. 9: 1746. https://doi.org/10.3390/nu14091746

APA Style

Allweyer, M., Emde, M., Bähr, I., Spielmann, J., Bieramperl, P., Naujoks, W., & Kielstein, H. (2022). Investigation of Behavior and Plasma Levels of Corticosterone in Restrictive- and Ad Libitum-Fed Diet-Induced Obese Mice. Nutrients, 14(9), 1746. https://doi.org/10.3390/nu14091746

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop