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Nutrients
Volume 14
Issue 9
10.3390/nu14091984
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Article

Dried Ginger Extract Restores the T Helper Type 1/T Helper Type 2 Balance and Antibody Production in Cyclophosphamide-Induced Immunocompromised Mice after Flu Vaccination

by
Jihyun Kim
,
Hoyoung Lee
and
Sooseong You
*
KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2022, 14(9), 1984; https://doi.org/10.3390/nu14091984
Submission received: 20 April 2022 / Revised: 6 May 2022 / Accepted: 7 May 2022 / Published: 9 May 2022
(This article belongs to the Section Nutritional Immunology)
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Abstract

Dried ginger (Zingiberis Processum Rhizoma (ZR)) is frequently used to prevent or treat common cold and flu. This study aimed to investigate the influence of ZR extracts on influenza-specific antibody production in cyclophosphamide (Cy)-induced immunocompromised mice. Female BALB/c mice were injected three times with saline or Cy. To investigate the effect of ZR, either distilled water or ZR was administered orally to mice daily for 10 days after Cy injection. After ZR administration, the mice were immunized with the 2017/2018 influenza vaccine. Pretreatment with ZR extracts enhanced influenza-specific antibody production in Cy-induced immunocompromised mice after flu vaccination and restored the influenza antigen-specific T helper (Th) type 1/Th2 balance to the normal state. Further, ZR suppressed the eosinophil enrichment caused by Cy injection in the spleen. We demonstrated that ZR can be used to increase antibody production in immunocompromised individuals before vaccination.
Keywords: influenza vaccine; dried ginger; cyclophosphamide; antibody production; Th1/Th2 influenza vaccine; dried ginger; cyclophosphamide; antibody production; Th1/Th2
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MDPI and ACS Style

Kim, J.; Lee, H.; You, S. Dried Ginger Extract Restores the T Helper Type 1/T Helper Type 2 Balance and Antibody Production in Cyclophosphamide-Induced Immunocompromised Mice after Flu Vaccination. Nutrients 2022, 14, 1984. https://doi.org/10.3390/nu14091984

AMA Style

Kim J, Lee H, You S. Dried Ginger Extract Restores the T Helper Type 1/T Helper Type 2 Balance and Antibody Production in Cyclophosphamide-Induced Immunocompromised Mice after Flu Vaccination. Nutrients. 2022; 14(9):1984. https://doi.org/10.3390/nu14091984

Chicago/Turabian Style

Kim, Jihyun, Hoyoung Lee, and Sooseong You. 2022. "Dried Ginger Extract Restores the T Helper Type 1/T Helper Type 2 Balance and Antibody Production in Cyclophosphamide-Induced Immunocompromised Mice after Flu Vaccination" Nutrients 14, no. 9: 1984. https://doi.org/10.3390/nu14091984

APA Style

Kim, J., Lee, H., & You, S. (2022). Dried Ginger Extract Restores the T Helper Type 1/T Helper Type 2 Balance and Antibody Production in Cyclophosphamide-Induced Immunocompromised Mice after Flu Vaccination. Nutrients, 14(9), 1984. https://doi.org/10.3390/nu14091984

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