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Volume 15
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10.3390/nu15183909
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Article

Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences

by
Roger Bentanachs
1,2,
Laia Blanco
1,
Maria Montesinos
1,
Aleix Sala-Vila
3,4,
Iolanda Lázaro
3,4,
Jose Rodríguez-Morató
4,5,
Rosa María Sánchez
1,2,4,
Juan Carlos Laguna
1,2,4,
Núria Roglans
1,2,4,* and
Marta Alegret
1,2,4,*
1
Department of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain
2
Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain
3
IMIM-Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain
4
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
5
Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
Nutrients 2023, 15(18), 3909; https://doi.org/10.3390/nu15183909
Submission received: 26 July 2023 / Revised: 4 September 2023 / Accepted: 6 September 2023 / Published: 8 September 2023
(This article belongs to the Special Issue Sex Differences in Metabolism and Cardiometabolic Diseases)
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Abstract

Non-alcoholic fatty liver disease is a sexual dimorphic disease, with adipose tissue playing an essential role. Our previous work showed that female rats fed a high-fat high-fructose diet devoid of cholesterol (HFHFr) developed simple hepatic steatosis dissociated from obesity. This study assessed the impact of the HFHFr diet on the male rat metabolism compared with data obtained for female rats. A total of 16 Sprague Dawley (SD) male rats were fed either a control (standard rodent chow and water) or HFHFr (high-fat diet devoid of cholesterol, plus 10% fructose in drinking water) diet for 3 months. Unlike female rats, and despite similar increases in energy consumption, HFHFr males showed increased adiposity and hyperleptinemia. The expression of hormone-sensitive lipase in the subcutaneous white adipose tissue was enhanced, leading to high free fatty acid and glycerol serum levels. HFHFr males presented hypertriglyceridemia, but not hepatic steatosis, partially due to enhanced liver PPARα-related fatty acid β-oxidation and the VLDL-promoting effect of leptin. In conclusion, the SD rats showed a sex-related dimorphic response to the HFHFr diet. Contrary to previous results for HFHFr female rats, the male rats were able to expand the adipose tissue, increase fatty acid catabolism, or export it as VLDL, avoiding liver lipid deposition.
Keywords: adipose tissue; fructose; high-fat diet; leptin; non-esterified fatty acids adipose tissue; fructose; high-fat diet; leptin; non-esterified fatty acids
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MDPI and ACS Style

Bentanachs, R.; Blanco, L.; Montesinos, M.; Sala-Vila, A.; Lázaro, I.; Rodríguez-Morató, J.; Sánchez, R.M.; Laguna, J.C.; Roglans, N.; Alegret, M. Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences. Nutrients 2023, 15, 3909. https://doi.org/10.3390/nu15183909

AMA Style

Bentanachs R, Blanco L, Montesinos M, Sala-Vila A, Lázaro I, Rodríguez-Morató J, Sánchez RM, Laguna JC, Roglans N, Alegret M. Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences. Nutrients. 2023; 15(18):3909. https://doi.org/10.3390/nu15183909

Chicago/Turabian Style

Bentanachs, Roger, Laia Blanco, Maria Montesinos, Aleix Sala-Vila, Iolanda Lázaro, Jose Rodríguez-Morató, Rosa María Sánchez, Juan Carlos Laguna, Núria Roglans, and Marta Alegret. 2023. "Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences" Nutrients 15, no. 18: 3909. https://doi.org/10.3390/nu15183909

APA Style

Bentanachs, R., Blanco, L., Montesinos, M., Sala-Vila, A., Lázaro, I., Rodríguez-Morató, J., Sánchez, R. M., Laguna, J. C., Roglans, N., & Alegret, M. (2023). Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences. Nutrients, 15(18), 3909. https://doi.org/10.3390/nu15183909

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