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Review

Effect of the Ketogenic Diet on the Prophylaxis and Treatment of Diabetes Mellitus: A Review of the Meta-Analyses and Clinical Trials

by
Damian Dyńka
1,
Katarzyna Kowalcze
1,
Filip Ambrozkiewicz
2 and
Agnieszka Paziewska
1,3,*
1
Institute of Health Sciences, Faculty of Medical and Health Sciences, Siedlce University of Natural Sciences and Humanities, 08-110 Siedlce, Poland
2
Laboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 32300 Pilsen, Czech Republic
3
Department of Neuroendocrinology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2023, 15(3), 500; https://doi.org/10.3390/nu15030500
Submission received: 16 December 2022 / Revised: 14 January 2023 / Accepted: 16 January 2023 / Published: 18 January 2023
(This article belongs to the Special Issue Nutritional Support for Chronic Disease)

Abstract

The exponentially growing frequency of diagnosing diabetes mellitus means that a verification of the previous dietetic approach to treating the disease seems justified. The simultaneous growth of interest in the ketogenic diet and the development of knowledge in this field have contributed to the increasingly frequent application of the ketogenic diet in diabetes treatment. This paper also deals with that issue; its aim includes an extensive analysis of the influence of the ketogenic diet on the prophylaxis and treatment of diabetes. The paper has been prepared based on a wide, meticulous analysis of the available literature on the subject. Among other findings, a favorable effect of that nutrition model has been demonstrated on the values of glycated hemoglobin, glucose, insulin, or other metabolic parameters in diabetes patients. The effect of the ketogenic diet on the pharmacotherapy of type 1 and type 2 diabetes has been presented and compared with the standard nutritional management plan recommended for that disease. Further research is needed in this field, especially studies with a long follow-up period. The discussed articles report interesting therapeutic advantages to the ketogenic diet in comparison with standard diets.
Keywords: ketogenic diet; ketosis; diabetes mellitus; type 1 diabetes mellitus; type 2 diabetes mellitus; glycaemia; glycated hemoglobin; HbA1c; HOMA-IR; metabolic syndrome; chronic diseases; obesity; lipid profile; lipidaemia; prophylaxis; treatment; nutrition recommendation; nutrition intervention; ketogenic; dietary patterns; carbohydrates; PRISMA; Cochrane ketogenic diet; ketosis; diabetes mellitus; type 1 diabetes mellitus; type 2 diabetes mellitus; glycaemia; glycated hemoglobin; HbA1c; HOMA-IR; metabolic syndrome; chronic diseases; obesity; lipid profile; lipidaemia; prophylaxis; treatment; nutrition recommendation; nutrition intervention; ketogenic; dietary patterns; carbohydrates; PRISMA; Cochrane
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MDPI and ACS Style

Dyńka, D.; Kowalcze, K.; Ambrozkiewicz, F.; Paziewska, A. Effect of the Ketogenic Diet on the Prophylaxis and Treatment of Diabetes Mellitus: A Review of the Meta-Analyses and Clinical Trials. Nutrients 2023, 15, 500. https://doi.org/10.3390/nu15030500

AMA Style

Dyńka D, Kowalcze K, Ambrozkiewicz F, Paziewska A. Effect of the Ketogenic Diet on the Prophylaxis and Treatment of Diabetes Mellitus: A Review of the Meta-Analyses and Clinical Trials. Nutrients. 2023; 15(3):500. https://doi.org/10.3390/nu15030500

Chicago/Turabian Style

Dyńka, Damian, Katarzyna Kowalcze, Filip Ambrozkiewicz, and Agnieszka Paziewska. 2023. "Effect of the Ketogenic Diet on the Prophylaxis and Treatment of Diabetes Mellitus: A Review of the Meta-Analyses and Clinical Trials" Nutrients 15, no. 3: 500. https://doi.org/10.3390/nu15030500

APA Style

Dyńka, D., Kowalcze, K., Ambrozkiewicz, F., & Paziewska, A. (2023). Effect of the Ketogenic Diet on the Prophylaxis and Treatment of Diabetes Mellitus: A Review of the Meta-Analyses and Clinical Trials. Nutrients, 15(3), 500. https://doi.org/10.3390/nu15030500

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