Scytosiphon lomentaria Extract Ameliorates Obesity and Modulates Gut Microbiota in High-Fat-Diet-Fed Mice

Yan, Jing; Bak, Jinwoo; Go, Yula; Park, Jumin; Park, Minkyoung; Lee, Hae-Jeung; Kim, Hyemee

doi:10.3390/nu15040815

Open AccessArticle

Scytosiphon lomentaria Extract Ameliorates Obesity and Modulates Gut Microbiota in High-Fat-Diet-Fed Mice

by

Jing Yan

¹,

Jinwoo Bak

¹,

Yula Go

¹,

Jumin Park

¹,

Minkyoung Park

¹,

Hae-Jeung Lee

^2,*,†

and

Hyemee Kim

^1,*,†

¹

Department of Food Science and Nutrition & Kimchi Research Institute, Pusan National University, Busan 46241, Republic of Korea

²

Department of Food and Nutrition, Gachon University, Seongnam-si 13120, Republic of Korea

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Nutrients 2023, 15(4), 815; https://doi.org/10.3390/nu15040815

Submission received: 2 January 2023 / Revised: 30 January 2023 / Accepted: 2 February 2023 / Published: 5 February 2023

(This article belongs to the Section Phytochemicals and Human Health)

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Abstract

Scytosiphon lomentaria (SL) is a brown seaweed with antioxidant and anti-inflammatory properties; however, its effects on obesity are unknown. In this research, we investigated the anti-obesity properties and underlying mechanisms of the SL extract in vitro and in vivo. In 3T3-L1 preadipocytes, SL extract inhibited lipid accumulation, decreased the expression of Acc1, C/ebpa, Pparg mRNA and p-ACC1, and increased the expression of Ucp1 mRNA, UCP1 and p-AMPK. In animal experiments, mice were fed a chow diet, a high-fat diet (HF; 60% of calories as fat), and high-fat diet with SL extract (150 and 300 mg/kg body weight) for eight weeks (n = 10/group). SL extract reduced HF-induced weight gain, epididymal fat weight, fat cell size, LDL-C, leptin, fasting glucose, and glucose tolerance. In addition, SL extract had comparable effects on mRNA expression in WAT and liver to those observed in vitro, thereby inhibiting p-ACC1/ACC1 and increasing p-AMPK/AMPK and UCP1 expression. Furthermore, SL extract decreased HF-induced Firmicutes/Bacteroidetes ratio and reversed HF-reduced Bacteroides spp., Bacteroides vulgatus, and Faecalibacterium prausnitzii. These findings suggest that SL extract can aid in weight loss in mice fed a high-fat diet by altering adipogenic and thermogenic pathways, as well as gut microbiota composition.

Keywords: Scytosiphon lomentaria; mice; anti-obesity; gut microbiota

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MDPI and ACS Style

Yan, J.; Bak, J.; Go, Y.; Park, J.; Park, M.; Lee, H.-J.; Kim, H. Scytosiphon lomentaria Extract Ameliorates Obesity and Modulates Gut Microbiota in High-Fat-Diet-Fed Mice. Nutrients 2023, 15, 815. https://doi.org/10.3390/nu15040815

AMA Style

Yan J, Bak J, Go Y, Park J, Park M, Lee H-J, Kim H. Scytosiphon lomentaria Extract Ameliorates Obesity and Modulates Gut Microbiota in High-Fat-Diet-Fed Mice. Nutrients. 2023; 15(4):815. https://doi.org/10.3390/nu15040815

Chicago/Turabian Style

Yan, Jing, Jinwoo Bak, Yula Go, Jumin Park, Minkyoung Park, Hae-Jeung Lee, and Hyemee Kim. 2023. "Scytosiphon lomentaria Extract Ameliorates Obesity and Modulates Gut Microbiota in High-Fat-Diet-Fed Mice" Nutrients 15, no. 4: 815. https://doi.org/10.3390/nu15040815

APA Style

Yan, J., Bak, J., Go, Y., Park, J., Park, M., Lee, H.-J., & Kim, H. (2023). Scytosiphon lomentaria Extract Ameliorates Obesity and Modulates Gut Microbiota in High-Fat-Diet-Fed Mice. Nutrients, 15(4), 815. https://doi.org/10.3390/nu15040815

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Scytosiphon lomentaria Extract Ameliorates Obesity and Modulates Gut Microbiota in High-Fat-Diet-Fed Mice

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