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Volume 15
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10.3390/nu15081960
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Article

Anti-Steatotic Effects of Chlorella vulgaris, Nannochloropsis gaditana and Gracilaria vermiculophylla Algae Extracts in AML-12 Hepatocytes

by
Maitane González-Arceo
1,
Jenifer Trepiana
1,2,3,*,
Leixuri Aguirre
1,2,3,*,
Jone Ibarruri
4,
Marta Martínez-Sanz
5,
Marta Cebrián
4,
Isidra Recio
5,
María P. Portillo
1,2,3 and
Saioa Gómez-Zorita
1,2,3
1
Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, 01006 Vitoria-Gasteiz, Spain
2
CIBEROBN Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, 01006 Vitoria-Gasteiz, Spain
3
Bioaraba Health Research Institute, 01006 Vitoria-Gasteiz, Spain
4
AZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, Astondo Bidea, 609, 48160 Derio, Spain
5
Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), Nicolás Cabrera, 9, 28049 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Nutrients 2023, 15(8), 1960; https://doi.org/10.3390/nu15081960
Submission received: 21 March 2023 / Revised: 13 April 2023 / Accepted: 18 April 2023 / Published: 19 April 2023
(This article belongs to the Special Issue Food and Botanical Derived Phytoextracts for Health Benefits)
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Abstract

Non-alcoholic fatty liver disease (NAFLD) is considered the most common chronic liver alteration whose prevalence is increasing in Western countries. Microalgae and macroalgae have attracted great interest due to the high content in bioactive compounds with beneficial effects on health. The aim of the present study is to assess the potential interest of extracts rich in proteins obtained from the microalgae Chlorella vulgaris and Nannochloropsis gaditana and the macroalga Gracilaria vermiculophylla in the prevention of lipid accumulation in AML-12 hepatocytes. Toxicity was not observed at any of the tested doses. Both microalgae and the macroalga were effective in preventing triglyceride accumulation, with Nannochloropsis gaditana being the most effective one. Although the three algae extracts were able to increase different catabolic pathways involved in triglyceride metabolism, the mechanisms underlying the anti-steatotic effect were different in each algae extract. In conclusion, the present study demonstrates that Chlorella vulgaris, Nannochloropsis gaditana and Gracilaria vermiculophylla extracts are able to partially prevent the accumulation of triglycerides induced by palmitic acid in cultured hepatocytes, a model used to mimic the steatosis induced in liver by dietary patterns rich in saturated fat.
Keywords: microalgae; macroalgae; seaweed; extracts; non-alcoholic fatty liver disease; steatosis; proteins; lipid metabolism microalgae; macroalgae; seaweed; extracts; non-alcoholic fatty liver disease; steatosis; proteins; lipid metabolism
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MDPI and ACS Style

González-Arceo, M.; Trepiana, J.; Aguirre, L.; Ibarruri, J.; Martínez-Sanz, M.; Cebrián, M.; Recio, I.; Portillo, M.P.; Gómez-Zorita, S. Anti-Steatotic Effects of Chlorella vulgaris, Nannochloropsis gaditana and Gracilaria vermiculophylla Algae Extracts in AML-12 Hepatocytes. Nutrients 2023, 15, 1960. https://doi.org/10.3390/nu15081960

AMA Style

González-Arceo M, Trepiana J, Aguirre L, Ibarruri J, Martínez-Sanz M, Cebrián M, Recio I, Portillo MP, Gómez-Zorita S. Anti-Steatotic Effects of Chlorella vulgaris, Nannochloropsis gaditana and Gracilaria vermiculophylla Algae Extracts in AML-12 Hepatocytes. Nutrients. 2023; 15(8):1960. https://doi.org/10.3390/nu15081960

Chicago/Turabian Style

González-Arceo, Maitane, Jenifer Trepiana, Leixuri Aguirre, Jone Ibarruri, Marta Martínez-Sanz, Marta Cebrián, Isidra Recio, María P. Portillo, and Saioa Gómez-Zorita. 2023. "Anti-Steatotic Effects of Chlorella vulgaris, Nannochloropsis gaditana and Gracilaria vermiculophylla Algae Extracts in AML-12 Hepatocytes" Nutrients 15, no. 8: 1960. https://doi.org/10.3390/nu15081960

APA Style

González-Arceo, M., Trepiana, J., Aguirre, L., Ibarruri, J., Martínez-Sanz, M., Cebrián, M., Recio, I., Portillo, M. P., & Gómez-Zorita, S. (2023). Anti-Steatotic Effects of Chlorella vulgaris, Nannochloropsis gaditana and Gracilaria vermiculophylla Algae Extracts in AML-12 Hepatocytes. Nutrients, 15(8), 1960. https://doi.org/10.3390/nu15081960

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