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Article

Dietary Supplementation with an Extract of Aloysia citrodora (Lemon verbena) Improves Sleep Quality in Healthy Subjects: A Randomized Double-Blind Controlled Study

by
Silvia Pérez-Piñero
1,
Juan Carlos Muñoz-Carrillo
1,*,
Jon Echepare-Taberna
1,
Macarena Muñoz-Cámara
1,
Cristina Herrera-Fernández
1,
Ana I. García-Guillén
1,
Vicente Ávila-Gandía
1,
Pau Navarro
2,
Nuria Caturla
2,
Jonathan Jones
2 and
Francisco Javier López-Román
1,3
1
Faculty of Medicine, UCAM Universidad Católica San Antonio de Murcia, Carretera de Guadalupe s/n, 30107 Murcia, Spain
2
Monteloeder s.l., Miguel Servet 16, 03203 Elche, Spain
3
Primary Care Research Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(10), 1523; https://doi.org/10.3390/nu16101523
Submission received: 9 April 2024 / Revised: 3 May 2024 / Accepted: 15 May 2024 / Published: 18 May 2024
(This article belongs to the Special Issue Associations between Sleep, Nutrition, and Health)
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Abstract

Seventy-one healthy subjects with sleep disturbances participated in a randomized, double-blind controlled trial in which dietary supplementation with an extract of Aloysia citrodora (lemon verbena) (n = 33) or placebo (n = 38) was administered for 90 days. There were between-group differences in favor of the experimental group in the visual analogue scale (VAS) for sleep quality (6.5 ± 1.6 vs. 5.5 ± 2.1, p = 0.021) as well as in the overall score (5.8 ± 2.4, p = 0.008) and scores for sleep latency (1.6 ± 1.0 vs. 1.9 ± 0.7, p = 0.027) and sleep efficiency (84.5 ± 12.8 vs. 79.8 ± 13.6, p = 0.023) in the Pittsburgh Sleep Quality Index (PSQI). Sleep-related variables (latency, efficiency, wakefulness after sleep onset, awakenings) assessed by actigraphy also showed better scores in the experimental group (p = 0.001). Plasma nocturnal melatonin levels also increased significantly in the experimental group (199.7 ± 135.3 vs. 174.7 ± 115.4 pg/mL, p = 0.048). Changes in anthropometric parameters and physical activity levels were not found. In summary, a dietary supplement of lemon verbena administered for 3 months was associated with a significant improvement in sleep quality as compared with placebo in a population of healthy subjects with sleep problems.
Keywords: sleep disorders; insomnia; Aloysia citrodora; lemon verbena; stress; melatonin; cortisol sleep disorders; insomnia; Aloysia citrodora; lemon verbena; stress; melatonin; cortisol

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MDPI and ACS Style

Pérez-Piñero, S.; Muñoz-Carrillo, J.C.; Echepare-Taberna, J.; Muñoz-Cámara, M.; Herrera-Fernández, C.; García-Guillén, A.I.; Ávila-Gandía, V.; Navarro, P.; Caturla, N.; Jones, J.; et al. Dietary Supplementation with an Extract of Aloysia citrodora (Lemon verbena) Improves Sleep Quality in Healthy Subjects: A Randomized Double-Blind Controlled Study. Nutrients 2024, 16, 1523. https://doi.org/10.3390/nu16101523

AMA Style

Pérez-Piñero S, Muñoz-Carrillo JC, Echepare-Taberna J, Muñoz-Cámara M, Herrera-Fernández C, García-Guillén AI, Ávila-Gandía V, Navarro P, Caturla N, Jones J, et al. Dietary Supplementation with an Extract of Aloysia citrodora (Lemon verbena) Improves Sleep Quality in Healthy Subjects: A Randomized Double-Blind Controlled Study. Nutrients. 2024; 16(10):1523. https://doi.org/10.3390/nu16101523

Chicago/Turabian Style

Pérez-Piñero, Silvia, Juan Carlos Muñoz-Carrillo, Jon Echepare-Taberna, Macarena Muñoz-Cámara, Cristina Herrera-Fernández, Ana I. García-Guillén, Vicente Ávila-Gandía, Pau Navarro, Nuria Caturla, Jonathan Jones, and et al. 2024. "Dietary Supplementation with an Extract of Aloysia citrodora (Lemon verbena) Improves Sleep Quality in Healthy Subjects: A Randomized Double-Blind Controlled Study" Nutrients 16, no. 10: 1523. https://doi.org/10.3390/nu16101523

APA Style

Pérez-Piñero, S., Muñoz-Carrillo, J. C., Echepare-Taberna, J., Muñoz-Cámara, M., Herrera-Fernández, C., García-Guillén, A. I., Ávila-Gandía, V., Navarro, P., Caturla, N., Jones, J., & López-Román, F. J. (2024). Dietary Supplementation with an Extract of Aloysia citrodora (Lemon verbena) Improves Sleep Quality in Healthy Subjects: A Randomized Double-Blind Controlled Study. Nutrients, 16(10), 1523. https://doi.org/10.3390/nu16101523

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