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Nutrients
Volume 16
Issue 12
10.3390/nu16121867
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Article

Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance

by
Yunna Kim
1,2,3,
Won Kyung Lee
4,
Hyein Jeong
5,
Hyuck Jai Choi
6,
Mi-Kyung Lee
5,* and
Seung-Hun Cho
1,2,3,*
1
College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
2
Kyung Hee University Medical Center, Kyung Hee University, Seoul 02447, Republic of Korea
3
Research Group of Neuroscience, East-West Medical Research Institute, WHO Collaborating Center, Kyung Hee University, Seoul 02447, Republic of Korea
4
LG H&H R&D Campus, Daejeon 34114, Republic of Korea
5
LG Science Park in Magok, LG H&H Co., Ltd., Seoul 07795, Republic of Korea
6
Korean Society for Pharmacoepidemiology and Risk Management, Seoul 16499, Republic of Korea
*
Authors to whom correspondence should be addressed.
Nutrients 2024, 16(12), 1867; https://doi.org/10.3390/nu16121867
Submission received: 9 May 2024 / Revised: 3 June 2024 / Accepted: 12 June 2024 / Published: 14 June 2024
(This article belongs to the Special Issue Nutritional Value and Health Benefits of Dietary Bioactive Compounds)
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Abstract

Chronic sleep disturbance affects daily functioning, leading to decreased concentration, fatigue, and higher healthcare costs. Traditional insomnia medications are often associated with adverse side effects. This study investigated the efficacy of a novel compound derived from Rhodiola rosea and Nelumbo nucifera extracts (named RNE) in improving sleep quality with fewer side effects. The study included individuals between the ages of 20 and 65 with subthreshold insomnia and evaluated the effects of RNE on sleep, fatigue, and quality of life. Participants took 750 mg of RNE daily at bed-time for two weeks. The study used the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), a sleep diary, the Fatigue Severity Scale (FSS), and the Short Form 36 Health Survey (SF-36) for assessments. Of the 20 participants, 13 completed the study and showed significant improvements in sleep quality. The results showed improvements in ISI and PSQI scores, a 57% reduction in wake-time after sleep onset, and improved sleep efficiency. Although FSS scores remained unchanged, significant improvements were seen in SF-36 physical and mental health scores. The results suggest that RNE is an effective, low-risk option for sleep disturbance, significantly improving sleep quality and overall wellbeing without significant side effects.
Keywords: sleep disturbance; Rhodiola rosea; Nelumbo nucifera; natural product; dietary supplement; ISI sleep disturbance; Rhodiola rosea; Nelumbo nucifera; natural product; dietary supplement; ISI

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MDPI and ACS Style

Kim, Y.; Lee, W.K.; Jeong, H.; Choi, H.J.; Lee, M.-K.; Cho, S.-H. Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance. Nutrients 2024, 16, 1867. https://doi.org/10.3390/nu16121867

AMA Style

Kim Y, Lee WK, Jeong H, Choi HJ, Lee M-K, Cho S-H. Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance. Nutrients. 2024; 16(12):1867. https://doi.org/10.3390/nu16121867

Chicago/Turabian Style

Kim, Yunna, Won Kyung Lee, Hyein Jeong, Hyuck Jai Choi, Mi-Kyung Lee, and Seung-Hun Cho. 2024. "Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance" Nutrients 16, no. 12: 1867. https://doi.org/10.3390/nu16121867

APA Style

Kim, Y., Lee, W. K., Jeong, H., Choi, H. J., Lee, M.-K., & Cho, S.-H. (2024). Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance. Nutrients, 16(12), 1867. https://doi.org/10.3390/nu16121867

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