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Open AccessArticle
Genetic Factors Contributing to Interindividual Variability in α-Tocopherol Levels in Subcutaneous Adipose Tissue among Healthy Adult Males
by
Mark Pretzel Zumaraga
Mark Pretzel Zumaraga 1,2,†,
Patrick Borel
Patrick Borel 1,†
,
Beatrice Gleize
Beatrice Gleize 1,‡
,
Marion Nowicki
Marion Nowicki 1
,
Djaffar Ould-Ali
Djaffar Ould-Ali 3,
Jean-François Landrier
Jean-François Landrier 1
and
Charles Desmarchelier
Charles Desmarchelier 1,4,*
1
Center for CardioVascular and Nutrition Research (C2VN), Aix Marseille Université, INSERM, INRAE, 13005 Marseille, France
2
Department of Science and Technology-Food and Nutrition Research Institute, Bicutan, Taguig City 1631, Philippines
3
Plastic & Anesthetic Surgery Department, Clinique Internationale du Parc Monceau, 75017 Paris, France
4
Institut Universitaire de France (IUF), 75000 Paris, France
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
Current address: UMR 408 SQPOV, INRAE, Avignon Université, 84000 Avignon, France.
Nutrients 2024, 16(15), 2556; https://doi.org/10.3390/nu16152556 (registering DOI)
Submission received: 4 July 2024
/
Revised: 25 July 2024
/
Accepted: 26 July 2024
/
Published: 3 August 2024
Abstract
In humans, α-tocopherol (α-TOC) is mainly stored in adipose tissue, where it participates in preventing damages induced by inflammation and reactive oxygen species. Factors, including genetic ones, that explain adipose tissue α-TOC concentration remain poorly understood. This study, therefore, aimed to characterize the interindividual variability of adipose tissue α-TOC concentration in healthy individuals and to identify single nucleotide polymorphisms (SNPs) associated with it. The study used a randomized cross-over design with 42 healthy adult males. α-TOC concentration was measured in fasting plasma and periumbilical adipose tissue samples, both at fast and 8 h after consumption of three standard meals. Partial least squares (PLS) regression was performed to identify SNPs associated with the interindividual variability of adipose tissue α-TOC concentration. Adipose tissue α-TOC concentration was not associated with fasting plasma concentration (Pearson’s r = 0.24, 95% CI: [−0.08, 0.51]). There was a high interindividual variability in adipose tissue α-TOC concentration (CV = 61%). A PLS regression model comprising 10 SNPs in five genes (PPARG, ABCA1, BUD13, CD36, and MGLL) explained 60% (adjusted R2) of the variability of this concentration. The interindividual variability of adipose tissue α-TOC concentration in humans is due, at least partly, to SNPs in genes involved in α-TOC and triglyceride metabolism.
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MDPI and ACS Style
Zumaraga, M.P.; Borel, P.; Gleize, B.; Nowicki, M.; Ould-Ali, D.; Landrier, J.-F.; Desmarchelier, C.
Genetic Factors Contributing to Interindividual Variability in α-Tocopherol Levels in Subcutaneous Adipose Tissue among Healthy Adult Males. Nutrients 2024, 16, 2556.
https://doi.org/10.3390/nu16152556
AMA Style
Zumaraga MP, Borel P, Gleize B, Nowicki M, Ould-Ali D, Landrier J-F, Desmarchelier C.
Genetic Factors Contributing to Interindividual Variability in α-Tocopherol Levels in Subcutaneous Adipose Tissue among Healthy Adult Males. Nutrients. 2024; 16(15):2556.
https://doi.org/10.3390/nu16152556
Chicago/Turabian Style
Zumaraga, Mark Pretzel, Patrick Borel, Beatrice Gleize, Marion Nowicki, Djaffar Ould-Ali, Jean-François Landrier, and Charles Desmarchelier.
2024. "Genetic Factors Contributing to Interindividual Variability in α-Tocopherol Levels in Subcutaneous Adipose Tissue among Healthy Adult Males" Nutrients 16, no. 15: 2556.
https://doi.org/10.3390/nu16152556
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