Maternal Docosahexaenoic Acid Supplementation Alters Maternal and Fetal Docosahexaenoic Acid Status and Placenta Phospholipids in Pregnancies Complicated by High Body Mass Index
Abstract
:1. Introduction
2. Methods
2.1. Sample Collection
2.2. Total DHA Quantification
2.3. Phospholipid Analysis
2.4. Choline Analysis
2.5. Statistics
3. Results
3.1. Clinical Characteristics
3.2. Maternal, Fetal, Placental DHA Status
3.3. Placental DHA-Phospholipid Concentrations
3.4. Placental Phospholipids
3.5. Choline Status
4. Discussion
5. Limitations
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Control | High BMI | p Values | |||||
---|---|---|---|---|---|---|---|
DHA Supplementation (mg/d) | 0 | 200 | 0 | 200 | BMI | Supp | B*S |
N | 10 | 7 | 6 | 7 | |||
Maternal Age | 30.9 ± 1.97 | 34.0 ± 2.12 | 30.0 ± 2.19 | 35.5 ± 1.23 | 0.88 | 0.04 | 0.56 |
BMI | 22.24 ± 0.57 | 22.1 ± 0.61 | 31.93 ± 2.33 | 30.1 ± 0.92 | <0.0001 | 0.38 | 0.45 |
Fetal Sex (M/F) | 5/5 | 2/6 | 2/4 | 5/1 |
Correlation with Corresponding Phosphatidic Acid Species | ||
---|---|---|
Species | R2 | p Value |
18:0_18:1 PC | 0.39 | 0.0003 |
18:0_18:2 PC | 0.67 | <0.0001 |
18:0_20:4 PC | 0.26 | 0.004 |
18:0_22:4 PC | 0.14 | 0.04 |
18:0_22:6 PC | 0.32 | 0.0013 |
18:0_18:1 PE | 0.38 | 0.0004 |
18:0_18:2 PE | 0.53 | <0.0001 |
18:0_20:4 PE | 0.15 | 0.04 |
18:0_22:4 PE | 0.24 | 0.008 |
18:0_22:5 PE | 0.33 | 0.0014 |
18:0_22:6 PE | 0.33 | 0.0011 |
18:0_18:1 PI | 0.62 | <0.0001 |
18:0_18:2 PI | 0.75 | <0.0001 |
18:0_20:4 PI | 0.22 | 0.01 |
18:0_22:4 PI | 0.34 | 0.001 |
18:0_22:5 PI | 0.22 | 0.01 |
18:0_22:6 PI | 0.56 | <0.0001 |
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Bidne, K.L.; Zemski Berry, K.; Dillon, M.; Jansson, T.; Powell, T.L. Maternal Docosahexaenoic Acid Supplementation Alters Maternal and Fetal Docosahexaenoic Acid Status and Placenta Phospholipids in Pregnancies Complicated by High Body Mass Index. Nutrients 2024, 16, 2934. https://doi.org/10.3390/nu16172934
Bidne KL, Zemski Berry K, Dillon M, Jansson T, Powell TL. Maternal Docosahexaenoic Acid Supplementation Alters Maternal and Fetal Docosahexaenoic Acid Status and Placenta Phospholipids in Pregnancies Complicated by High Body Mass Index. Nutrients. 2024; 16(17):2934. https://doi.org/10.3390/nu16172934
Chicago/Turabian StyleBidne, Katie L., Karin Zemski Berry, Mairead Dillon, Thomas Jansson, and Theresa L. Powell. 2024. "Maternal Docosahexaenoic Acid Supplementation Alters Maternal and Fetal Docosahexaenoic Acid Status and Placenta Phospholipids in Pregnancies Complicated by High Body Mass Index" Nutrients 16, no. 17: 2934. https://doi.org/10.3390/nu16172934