Monitoring the Quality of Life and the Relationship between Quality of Life, Dietary Intervention, and Dietary Adherence in Patients with Coeliac Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Population
2.2. Study Design
2.3. Quality of Life Assessment
2.4. Assessment of Dietary Adherence
2.5. Statistical Analysis
2.6. Ethics
3. Results
3.1. CD-QoL Scores
3.2. CDAT Results
4. Discussion
4.1. Quality of Life Assessment
4.2. Dietary Adherence
4.3. Association between CDAT and QoL
4.4. Strengths and Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group I | Inclusion (n = 32) (Informed Consent/Screening) | Visit 1 V1 | Visit 2 V2 | Visit 3 V3 | |
---|---|---|---|---|---|
Dietetic intervention | x | x | x | ||
CDAT | x | x | x | ||
CD-QoL | x | x | x | ||
Serology (tTG) | x | x | x | ||
Group II | Inclusion (n = 19) (Informed Consent/Screening) | Visit 0 (GFD for 0 month) V0 | Visit 1 (GFD for 3 month) V1 | Visit 2 (GFD for 6 month) V2 | Visit 3 (GFD for 12 month) V3 |
Dietetic intervention | x | x | x | x | |
CDAT | - | x | x | x | |
CD-QoL | - | x | x | x | |
Serology (tTG) | x | x | x | x | |
Serology (EMA/DGP) | x | - | - | - |
Group I | Group II | |
---|---|---|
n (%) | 32 (62.7) | 19 (37.3) |
Age (years), mean ± SD | 34.5 ± 12.0 | 38.4 ± 11.2 |
Female, n (%) | 24 (75.0) | 14 (73.7) |
Years since CD diagnosis, mean ± SD (min–max) | 5.2 ± 6.3 (0.25–23) | - |
Groups | n | Minimum | Maximum | M | SD | |
---|---|---|---|---|---|---|
Group I | QoL 1 total score | 32 | 28 | 71 | 43.28 | 11.86 |
QoL 2 total score | 27 | 25 | 79 | 41.7 | 12.74 | |
QoL 3 total score | 21 | 28 | 73 | 41.14 | 11.29 | |
Group II | QoL 1 total score | 19 | 26 | 78 | 43.63 | 13.08 |
QoL 2 total score | 16 | 24 | 69 | 40.56 | 11.83 | |
QoL 3 total score | 10 | 25 | 71 | 37.7 | 13.87 |
Group I (n = 21) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
V1 | V2 | V3 | F | p | η2p * | Post Hoc | ||||
M | SD | M | SD | M | SD | |||||
QoL (Total) | 44.24 | 11.69 | 41.90 | 13.13 | 41.14 | 11.29 | 2.017 | 0.146 | 0.09 | |
Limitations | 22.71 | 5.77 | 21.33 | 6.42 | 20.52 | 6.26 | 3.236 | 0.050 | 0.14 | |
Dysphoria | 6.95 | 3.07 | 6.76 | 3.55 | 5.90 | 2.36 | 3.759 | 0.032 | 0.16 | V1 = V2, V1 > V3, V2 = V3 |
Health Concerns | 10.24 | 4.07 | 10.05 | 3.58 | 10.57 | 3.71 | 0.541 | 0.586 | 0.03 | |
Inadequate Treatment | 6.10 | 2.12 | 6.00 | 1.61 | 5.38 | 1.20 | 1.943 | 0.157 | 0.09 | |
Group II (n = 10) | ||||||||||
V1 | V2 | V3 | F | p | η2p * | Post hoc | ||||
M | SD | M | SD | M | SD | |||||
QoL (Total) | 40.90 | 10.83 | 40.80 | 11.42 | 37.70 | 13.87 | 1.395 | 0.273 | 0.13 | |
Limitations | 20.70 | 6.65 | 21.50 | 6.21 | 20.50 | 7.61 | 0.262 | 0.772 | 0.03 | |
Dysphoria | 6.00 | 2.06 | 5.60 | 2.22 | 5.50 | 2.46 | 0.654 | 0.532 | 0.07 | |
Health Concerns | 10.10 | 4.70 | 9.50 | 3.69 | 8.50 | 3.66 | 0.827 | 0.453 | 0.08 | |
Inadequate Treatment | 7.00 | 2.67 | 6.80 | 1.75 | 6.10 | 1.66 | 0.639 | 0.539 | 0.07 |
CDAT3—Total Score | Serology (tTG-IgA) | ||||||
---|---|---|---|---|---|---|---|
n | Minimum | Maximum | M | SD | Negative | Positive | |
Group I | 13 | 7 | 19 | 12.23 | 3.30 | 8 | 5 |
Group II | 10 | 10 | 18 | 12.7 | 2.58 | 6 | 4 |
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Dakó, E.; Dakó, S.; Papp, V.; Juhász, M.; Takács, J.; Csobod, É.C.; Pálfi, E. Monitoring the Quality of Life and the Relationship between Quality of Life, Dietary Intervention, and Dietary Adherence in Patients with Coeliac Disease. Nutrients 2024, 16, 2964. https://doi.org/10.3390/nu16172964
Dakó E, Dakó S, Papp V, Juhász M, Takács J, Csobod ÉC, Pálfi E. Monitoring the Quality of Life and the Relationship between Quality of Life, Dietary Intervention, and Dietary Adherence in Patients with Coeliac Disease. Nutrients. 2024; 16(17):2964. https://doi.org/10.3390/nu16172964
Chicago/Turabian StyleDakó, Eszter, Sarolta Dakó, Veronika Papp, Márk Juhász, Johanna Takács, Éva Csajbókné Csobod, and Erzsébet Pálfi. 2024. "Monitoring the Quality of Life and the Relationship between Quality of Life, Dietary Intervention, and Dietary Adherence in Patients with Coeliac Disease" Nutrients 16, no. 17: 2964. https://doi.org/10.3390/nu16172964