Abstract
Manihot esculenta (cassava) roots is a major food crop for its energy content. Leaves contain nutrients and demonstrate biological properties but remain undervalorized. In order to develop a bioguided optimization of cassava nutrition–health properties, we compared the phytochemistry and bioactive potential of cassava root flour extract (CF) with cassava flour extract enriched with 30% leaves powder (CFL). Cassava flour supplementation impact was explored on flour composition (starch, fiber, carotenoids, phenolic compounds), in vivo glycemic index, and bioactivity potential using macrophage cells. We assessed the impact of cassava flour supplementation on free radicals scavenging and cellular production of pro-inflammatory mediators. CFL showed higher levels of fiber, carotenoids, phenolic compounds, and lower glycemic index. Significantly higher bioactive properties (anti-inflammatory and antioxidant) were recorded, and inhibition of cytokines production has been demonstrated as a function of extract concentration. Overall, our results indicate that enrichment of cassava flour with leaves significantly enhances its nutrition–health and bioactive potential. This bioguided matrix recombination approach may be of interest to provide prophylactic and therapeutic dietary strategy to manage malnutrition and associated chronic non-communicable diseases characterized by low-grade inflammation and unbalanced redox status. It would also promote a more efficient use of available food resources.
Share and Cite
MDPI and ACS Style
Boukhers, I.; Domingo, R.; Septembre-Malaterre, A.; Antih, J.; Silvestre, C.; Petit, T.; Kodja, H.; Poucheret, P.
Bioguided Optimization of the Nutrition-Health, Antioxidant, and Immunomodulatory Properties of Manihot esculenta (Cassava) Flour Enriched with Cassava Leaves. Nutrients 2024, 16, 3023.
https://doi.org/10.3390/nu16173023
AMA Style
Boukhers I, Domingo R, Septembre-Malaterre A, Antih J, Silvestre C, Petit T, Kodja H, Poucheret P.
Bioguided Optimization of the Nutrition-Health, Antioxidant, and Immunomodulatory Properties of Manihot esculenta (Cassava) Flour Enriched with Cassava Leaves. Nutrients. 2024; 16(17):3023.
https://doi.org/10.3390/nu16173023
Chicago/Turabian Style
Boukhers, Imane, Romain Domingo, Axelle Septembre-Malaterre, Julien Antih, Charlotte Silvestre, Thomas Petit, Hippolyte Kodja, and Patrick Poucheret.
2024. "Bioguided Optimization of the Nutrition-Health, Antioxidant, and Immunomodulatory Properties of Manihot esculenta (Cassava) Flour Enriched with Cassava Leaves" Nutrients 16, no. 17: 3023.
https://doi.org/10.3390/nu16173023
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article Access Statistics
For more information on the journal statistics, click
here.
Multiple requests from the same IP address are counted as one view.