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Open AccessArticle
The Temporal Change in Ionised Calcium, Parathyroid Hormone and Bone Metabolism Following Ingestion of a Plant-Sourced Marine Mineral + Protein Isolate in Healthy Young Adults
by
Marta Kozior
Marta Kozior 1,
Olusoji Aboyeji Demehin
Olusoji Aboyeji Demehin 2,
Michelle Mary Ryan
Michelle Mary Ryan 2,
Sean O’Connell
Sean O’Connell 2,3 and
Philip Michael Jakeman
Philip Michael Jakeman
Prof. Philip M. Jakeman is a foundation member of the Health Research Institute at the University of [...]
Prof. Philip M. Jakeman is a foundation member of the Health Research Institute at the University of Limerick. A graduate of biochemistry and human exercise science, he acts as the lead PI to the Human Science Research Group at UL and Food for Health Ireland’s ‘Healthy Ageing and Performance Nutrition’ Health Pillar. The research group maintains close collaboration with the food industry, engaging in innovative projects designing and evaluating the bioefficacy of nutrient intake and the outcomes in translation to human intervention studies in specific populations. His special interests include muscle physiology and biochemistry, muscle metabolism, exercise metabolism, cell biology, and human body composition.
1,*
1
Food, Diet and Nutrition, Health Research Institute, University of Limerick, V94 T9PX Limerick, Ireland
2
Shannon Applied Technology Centre, Munster Technological University, Clash, V92 CX88 Tralee, Ireland
3
Marigot Research Centre, Sycamore Court, V92 N6C8 Tralee, Ireland
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(18), 3110; https://doi.org/10.3390/nu16183110 (registering DOI)
Submission received: 31 July 2024
/
Revised: 11 September 2024
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Accepted: 13 September 2024
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Published: 14 September 2024
Abstract
Abstract: Background: An increase in plant-sourced (PS) nutrient intake is promoted in support of a sustainable diet. PS dietary minerals and proteins have bioactive properties that can affect bone health and the risk of fracture. Methods: In a group randomised, cross-over design, this study evaluated the post-ingestion temporal pattern of change in arterialised ionised calcium (iCa), parathyroid hormone (PTH), C-terminal crosslinked telopeptide of type I collagen (CTX) and procollagen type 1 amino-terminal propeptide (P1NP) for 4 h following ingestion of a novel supplement (SUPP) containing a PS marine multi-mineral + PS protein isolate. A diurnally matched intake of mineral water was used as a control (CON). Results: Compared to baseline, the change in iCa concentration was 0.022 (95%CI, 0.006 to 0.038, p = 0.011) mmol/l greater in SUPP than CON, resulting in a −4.214 (95%CI, −8.244 to −0.183, p = 0.042) pg/mL mean reduction in PTH, a −0.64 (95%CI, −0.199 to −0.008, p = 0.029) ng/mL decrease in the biomarker of bone resorption, CTX, and no change in the biomarker of bone formation, P1NP. Conclusions: When used as a dietary supplement, or incorporated into a food matrix, the promotion of PS marine multi-mineral and PS protein isolates may contribute to a more sustainable diet and overall bone health.
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MDPI and ACS Style
Kozior, M.; Demehin, O.A.; Ryan, M.M.; O’Connell, S.; Jakeman, P.M.
The Temporal Change in Ionised Calcium, Parathyroid Hormone and Bone Metabolism Following Ingestion of a Plant-Sourced Marine Mineral + Protein Isolate in Healthy Young Adults. Nutrients 2024, 16, 3110.
https://doi.org/10.3390/nu16183110
AMA Style
Kozior M, Demehin OA, Ryan MM, O’Connell S, Jakeman PM.
The Temporal Change in Ionised Calcium, Parathyroid Hormone and Bone Metabolism Following Ingestion of a Plant-Sourced Marine Mineral + Protein Isolate in Healthy Young Adults. Nutrients. 2024; 16(18):3110.
https://doi.org/10.3390/nu16183110
Chicago/Turabian Style
Kozior, Marta, Olusoji Aboyeji Demehin, Michelle Mary Ryan, Sean O’Connell, and Philip Michael Jakeman.
2024. "The Temporal Change in Ionised Calcium, Parathyroid Hormone and Bone Metabolism Following Ingestion of a Plant-Sourced Marine Mineral + Protein Isolate in Healthy Young Adults" Nutrients 16, no. 18: 3110.
https://doi.org/10.3390/nu16183110
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