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Emerging Roles for Sphingolipids in Cardiometabolic Disease: A Rational Therapeutic Target?
by
Daniel Foran
Daniel Foran ,
Charalambos Antoniades
Charalambos Antoniades
Prof. Charalambos Antoniades is the Director of the Acute Multidisciplinary Imaging and Centre of of [...]
Prof. Charalambos Antoniades is the Director of the Acute Multidisciplinary Imaging and Interventional Centre of the University of Oxford. Prof. Charalambos Antoniades graduated from the Athens Medical School in 2000 and was awarded his PhD title with hons on the genetics of premature myocardial infarction. He won multiple prestigious international Young Investigator award competitions and in 2016 he received the Outstanding Achievement award from the European Society of Cardiology. He is also a deputy editor of Cardiovascular Research, editor of the British Journal of Pharmacology, and associate editor of other journals. He is a Past Chair of the British Atherosclerosis Society of the British Atherosclerosis Society and one of the founders of the ESC Scientists of Tomorrow. Prof. Charalambos Antoniades is also the founder and Chief Scientific Officer of Caristo Diagnostics, a University of Oxford spinout company commercializing novel CT-derived biomarkers for cardiovascular risk prediction.
and
Ioannis Akoumianakis
Ioannis Akoumianakis *
Cardiovascular Medicine Division, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(19), 3296; https://doi.org/10.3390/nu16193296 (registering DOI)
Submission received: 8 August 2024
/
Revised: 19 September 2024
/
Accepted: 25 September 2024
/
Published: 28 September 2024
Abstract
Cardiovascular disease is a leading cause of morbidity and mortality. New research elucidates increasingly complex relationships between cardiac and metabolic health, giving rise to new possible therapeutic targets. Sphingolipids are a heterogeneous class of bioactive lipids with critical roles in normal human physiology. They have also been shown to play both protective and deleterious roles in the pathogenesis of cardiovascular disease. Ceramides are implicated in dysregulating insulin signalling, vascular endothelial function, inflammation, oxidative stress, and lipoprotein aggregation, thereby promoting atherosclerosis and vascular disease. Ceramides also advance myocardial disease by enhancing pathological cardiac remodelling and cardiomyocyte death. Glucosylceramides similarly contribute to insulin resistance and vascular inflammation, thus playing a role in atherogenesis and cardiometabolic dysfunction. Sphingosing-1-phosphate, on the other hand, may ameliorate some of the pathological functions of ceramide by protecting endothelial barrier integrity and promoting cell survival. Sphingosine-1-phosphate is, however, implicated in the development of cardiac fibrosis. This review will explore the roles of sphingolipids in vascular, cardiac, and metabolic pathologies and will evaluate the therapeutic potential in targeting sphingolipids with the aim of prevention and reversal of cardiovascular disease in order to improve long-term cardiovascular outcomes.
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MDPI and ACS Style
Foran, D.; Antoniades, C.; Akoumianakis, I.
Emerging Roles for Sphingolipids in Cardiometabolic Disease: A Rational Therapeutic Target? Nutrients 2024, 16, 3296.
https://doi.org/10.3390/nu16193296
AMA Style
Foran D, Antoniades C, Akoumianakis I.
Emerging Roles for Sphingolipids in Cardiometabolic Disease: A Rational Therapeutic Target? Nutrients. 2024; 16(19):3296.
https://doi.org/10.3390/nu16193296
Chicago/Turabian Style
Foran, Daniel, Charalambos Antoniades, and Ioannis Akoumianakis.
2024. "Emerging Roles for Sphingolipids in Cardiometabolic Disease: A Rational Therapeutic Target?" Nutrients 16, no. 19: 3296.
https://doi.org/10.3390/nu16193296
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