Next Article in Journal
The Effects of Polyphenol Supplementation on BDNF, Cytokines and Cognition in Trained Male Cyclists following Acute Ozone Exposure during High-Intensity Cycling
Next Article in Special Issue
Efficacy of a Low-FODMAP Diet for Coeliac Patients with Persistent IBS-like Symptoms despite a Gluten-Free Diet: A Systematic Review
Previous Article in Journal
Validation of Indirect Calorimetry in Children Undergoing Single-Limb Non-Invasive Ventilation: A Proof of Concept, Cross-Over Study
Previous Article in Special Issue
A Population-Based Cross-Sectional Study of Paediatric Coeliac Disease in Catalonia Showed a Downward Trend in Prevalence Compared to the Previous Decade
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 16
Issue 2
10.3390/nu16020232
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Improving the Diagnosis of Dermatitis Herpetiformis Using the Intraepithelial Lymphogram

by
Fernando Fernández-Bañares
1,2,
Laura Crespo
3,
Montserrat Planella
4,
Sergio Farrais
5,
Sandra Izquierdo
6,
Natalia López-Palacios
7,
Garbiñe Roy
8,
Judith Vidal
9 and
Concepción Núñez
10,11,*
1
Department of Gastroenterology, Hospital Universitari Mutua Terrassa, 08221 Terrasa, Spain
2
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain
3
Department of Gastroenterology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain
4
Department of Gastroenterology, Hospital Arnau Vilanova, 25198 Lleida, Spain
5
Department of Gastroenterology, Hospital Fundación Jiménez Díaz, 28040 Madrid, Spain
6
Department of Gastroenterology, Hospital Clínico Universitario, 47003 Valladolid, Spain
7
Department of Gastroenterology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, 28040 Madrid, Spain
8
Department of Immunology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, 28034 Madrid, Spain
9
Section of Flow Cytometry, CATLAB, 08232 Viladecavalls, Spain
10
Laboratorio de Investigación en Genética de Enfermedades Complejas, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, 28040 Madrid, Spain
11
Redes de Investigación Cooperativa Orientada a Resultados en Salud (RICORS), 28029 Madrid, Spain
 
add Show full affiliation list
 
remove Hide full affiliation list
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(2), 232; https://doi.org/10.3390/nu16020232
Submission received: 16 November 2023 / Revised: 4 January 2024 / Accepted: 9 January 2024 / Published: 11 January 2024
(This article belongs to the Special Issue Coeliac Disease, Microscopic Colitis and Exclusion Diets—a Commemorative Issue in Honour of Dr. Fernando Fernández-Bañares)
Browse Figures
Versions Notes

Abstract

Dermatitis herpetiformis is a cutaneous manifestation of celiac disease. Phenotyping of intraepithelial lymphocytes in the small bowel mucosa can strengthen the diagnosis of celiac disease when it is not clear-cut. We aim to evaluate the usefulness of the intraepithelial lymphogram to confirm dermatitis herpetiformis in equivocal cases. We performed a retrospective multicenter study on patients diagnosed with dermatitis herpetiformis and collected data from the intraepithelial lymphogram assessed by flow cytometry. A total of 36 patients were analyzed in relation to the severity of intestinal damage (18 had non-atrophic mucosa) at baseline (N = 28) and/or after the adoption of a gluten-free diet (median follow-up of three years, N = 16). We observed that patients with atrophy more often had positive celiac serology (p = 0.019), celiac clinical symptoms (p = 0.018), and iron-deficiency anemia (p = 0.018), but the severity of skin damage was similar in both groups (p = 0.79). At baseline, increased TCRγδ+ cells were present in 94% of patients with atrophy and 67% with non-atrophic lesions (p = 0.13). After a gluten-free diet, increased TCRγδ+ cells persisted in 100% and 63% of cases, respectively (p = 0.21). We concluded that increased TCRγδ+ cells may be helpful in confirming the diagnosis of dermatitis herpetiformis in equivocal cases, even in patients who were started on a gluten-free diet.
Keywords: dermatitis herpetiformis; celiac disease; celiac intraepithelial lymphogram; T-cell flow cytometry; gluten-free diet; TCRγδ+ cells dermatitis herpetiformis; celiac disease; celiac intraepithelial lymphogram; T-cell flow cytometry; gluten-free diet; TCRγδ+ cells

Share and Cite

MDPI and ACS Style

Fernández-Bañares, F.; Crespo, L.; Planella, M.; Farrais, S.; Izquierdo, S.; López-Palacios, N.; Roy, G.; Vidal, J.; Núñez, C. Improving the Diagnosis of Dermatitis Herpetiformis Using the Intraepithelial Lymphogram. Nutrients 2024, 16, 232. https://doi.org/10.3390/nu16020232

AMA Style

Fernández-Bañares F, Crespo L, Planella M, Farrais S, Izquierdo S, López-Palacios N, Roy G, Vidal J, Núñez C. Improving the Diagnosis of Dermatitis Herpetiformis Using the Intraepithelial Lymphogram. Nutrients. 2024; 16(2):232. https://doi.org/10.3390/nu16020232

Chicago/Turabian Style

Fernández-Bañares, Fernando, Laura Crespo, Montserrat Planella, Sergio Farrais, Sandra Izquierdo, Natalia López-Palacios, Garbiñe Roy, Judith Vidal, and Concepción Núñez. 2024. "Improving the Diagnosis of Dermatitis Herpetiformis Using the Intraepithelial Lymphogram" Nutrients 16, no. 2: 232. https://doi.org/10.3390/nu16020232

APA Style

Fernández-Bañares, F., Crespo, L., Planella, M., Farrais, S., Izquierdo, S., López-Palacios, N., Roy, G., Vidal, J., & Núñez, C. (2024). Improving the Diagnosis of Dermatitis Herpetiformis Using the Intraepithelial Lymphogram. Nutrients, 16(2), 232. https://doi.org/10.3390/nu16020232

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop