Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Baseline Characteristics of the Sample and Associations of GRS and MDS
3.2. Associations of GRS and MDS at Baseline and after the Food4Me Intervention with Metabolic Traits
4. Discussion
5. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Overall | GRS | p † | MDS | p † | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Low | High | Low | High | |||||||||
n (female) | 1263 | (722) | 640 | (354) | 623 | (368) | 0.177 | 747 | (419) | 516 | (303) | 0.353 |
Age (years) | 40.8 | ±13.0 | 41.2 | ±12.8 | 40.4 | ±13.1 | 0.357 | 40.2 | ±12.9 | 41.7 | ±13.0 | 0.034 |
Ethnicity n (% Caucasians) | 1224 | (96.9%) | 618 | (96.6%) | 606 | (97.3%) | 0.397 | 730 | (97.7%) | 494 | (95.7%) | 0.230 |
Smoke habit n (%) | ||||||||||||
Never smoker | 781 | (61.8%) | 392 | (61.3%) | 389 | (62.4%) | 0.902 | 473 | (63.3%) | 308 | (59.7%) | 0.294 |
Former smoker | 333 | (26.4%) | 172 | (26.9%) | 161 | (25.8%) | 185 | (24.8%) | 148 | (28.7%) | ||
Smoker | 149 | (11.8%) | 76 | (11.9%) | 73 | (11.7%) | 89 | (11.9%) | 60 | (11.6%) | ||
MDS (over 14) | 5.1 | ±1.7 | 5.1 | ±1.6 | 5.2 | ±1.7 | 0.529 | 4.0 | ±1.0 | 6.8 | ±0.9 | <0.001 |
GRS (over 28) | 10.5 | ±2.3 | 8.6 | ±1.3 | 12.4 | ±1.3 | <0.001 | 10.5 | ±2.3 | 10.5 | ±2.4 | 0.974 |
BMI (kg/m2) | 25.4 | ±4.7 | 25.2 | ±4.5 | 25.6 | ±4.8 | 0.018 | 25.6 | ±4.7 | 25.1 | ±4.6 | 0.012 |
Waist circumference (m) | 0.859 | ±0.136 | 0.857 | ±0.133 | 0.861 | ±0.140 | 0.052 | 0.866 | ±0.138 | 0.848 | ±0.134 | 0.001 |
Physical activity factor (AU) | 1.521 | ±0.104 | 1.525 | ±0.106 | 1.517 | ±0.101 | 0.094 | 1.516 | ±0.104 | 1.527 | ±0.103 | 0.021 |
Energy intake reported (kcal/day) | 2552 | ±1066 | 2609 | ±1086 | 2493 | ±1042 | 0.079 | 2512 | ±1060 | 2609 | ±1072 | 0.069 |
Glucose (mmol/L) | 3.73 | ±0.80 | 3.69 | ±0.80 | 3.77 | ±0.79 | 0.067 | 3.71 | ±0.75 | 3.76 | ±0.86 | 0.499 |
Total cholesterol (mmol/L) | 4.61 | ±0.95 | 4.61 | ±0.93 | 4.60 | ±0.97 | 0.601 | 4.64 | ±0.96 | 4.55 | ±0.93 | 0.008 |
Total carotenoids (μmol/L) | 1.52 | ±0.67 | 1.50 | ±0.64 | 1.55 | ±0.71 | 0.285 | 1.45 | ±0.60 | 1.64 | ±0.76 | <0.001 |
Omega3 index (AU) | 5.71 | ±1.22 | 5.70 | ±1.20 | 5.73 | ±1.24 | 0.377 | 5.53 | ±1.08 | 5.97 | ±1.35 | <0.001 |
Baseline GRS Category | p ‡ for Differences | ||||||
Low | p † | High | p † | ||||
BMI (kg/m2) | −0.281 | ±0.047 | <0.001 | −0.333 | ±0.044 | <0.001 | 0.417 |
Waist circumference (m) | −0.012 | ±0.002 | <0.001 | −0.012 | ±0.002 | <0.001 | 0.920 |
Glucose (mmol/L) | −0.251 | ±0.039 | <0.001 | −0.338 | ±0.039 | <0.001 | 0.114 |
Total cholesterol (mmol/L) | −0.209 | ±0.040 | <0.001 | −0.093 | ±0.041 | 0.024 | 0.043 |
Total carotenoids (μmol/L) | −0.043 | ±0.026 | 0.102 | −0.085 | ±0.028 | 0.003 | 0.282 |
Omega3 index (AU) | 0.217 | ±0.045 | <0.001 | 0.195 | ±0.044 | <0.001 | 0.718 |
Baseline MDS Category | p § for Differences | ||||||
Low | p † | High | p † | ||||
BMI (kg/m2) | −0.217 | ±0.044 | <0.001 | −0.397 | ±0.052 | <0.001 | 0.011 |
Waist circumference (m) | −0.009 | ±0.002 | <0.001 | −0.015 | ±0.002 | <0.001 | 0.010 |
Glucose (mmol/L) | −0.230 | ±0.036 | <0.001 | −0.360 | ±0.043 | <0.001 | 0.022 |
Total cholesterol (mmol/L) | −0.174 | ±0.042 | <0.001 | −0.127 | ±0.044 | 0.003 | 0.453 |
Total carotenoids (μmol/L) | −0.041 | ±0.024 | 0.097 | −0.087 | ±0.031 | 0.005 | 0.244 |
Omega3 index (AU) | 0.187 | ±0.038 | <0.001 | 0.225 | ±0.053 | <0.001 | 0.573 |
p † | GRS | p ‡ | ||||||
---|---|---|---|---|---|---|---|---|
Overall | Low | High | ||||||
BMI (kg/m2) | −0.065 | ±0.022 | 0.003 | −0.060 | ±0.024 | −0.069 | ±0.021 | 0.457 |
Waist circumference (m) | −0.002 | ±0.001 | 0.003 | −0.002 | ±0.001 | −0.002 | ±0.001 | 0.709 |
Glucose (mmol/L) | −0.050 | ±0.017 | 0.003 | −0.043 | ±0.018 | −0.057 | ±0.017 | 0.182 |
Total cholesterol (mmol/L) | 0.006 | ±0.018 | 0.753 | −0.004 | ±0.018 | 0.015 | ±0.018 | 0.058 |
Total carotenoids (μmol/L) | −0.018 | ±0.012 | 0.118 | −0.014 | ±0.012 | −0.023 | ±0.012 | 0.206 |
Omega3 index (AU) | −0.010 | ±0.019 | 0.611 | −0.007 | ±0.021 | −0.012 | ±0.020 | 0.677 |
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San-Cristobal, R.; Navas-Carretero, S.; Livingstone, K.M.; Celis-Morales, C.; Macready, A.L.; Fallaize, R.; O’Donovan, C.B.; Lambrinou, C.P.; Moschonis, G.; Marsaux, C.F.M.; et al. Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study. Nutrients 2017, 9, 1107. https://doi.org/10.3390/nu9101107
San-Cristobal R, Navas-Carretero S, Livingstone KM, Celis-Morales C, Macready AL, Fallaize R, O’Donovan CB, Lambrinou CP, Moschonis G, Marsaux CFM, et al. Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study. Nutrients. 2017; 9(10):1107. https://doi.org/10.3390/nu9101107
Chicago/Turabian StyleSan-Cristobal, Rodrigo, Santiago Navas-Carretero, Katherine M. Livingstone, Carlos Celis-Morales, Anna L. Macready, Rosalind Fallaize, Clare B. O’Donovan, Christina P. Lambrinou, George Moschonis, Cyril F. M. Marsaux, and et al. 2017. "Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study" Nutrients 9, no. 10: 1107. https://doi.org/10.3390/nu9101107