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Volume 15
Issue 2
10.3390/toxins15020164
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Review

Type II Toxin–Antitoxin Systems in Pseudomonas aeruginosa

by
Meng Li
,
Nannan Guo
,
Gaoyu Song
,
Yi Huang
,
Lecheng Wang
,
Yani Zhang
* and
Tietao Wang
*
Provincial Key Laboratory of Biotechnology, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi’an 710069, China
*
Authors to whom correspondence should be addressed.
Toxins 2023, 15(2), 164; https://doi.org/10.3390/toxins15020164
Submission received: 4 January 2023 / Revised: 3 February 2023 / Accepted: 14 February 2023 / Published: 17 February 2023
(This article belongs to the Section Bacterial Toxins)
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Abstract

Toxin–antitoxin (TA) systems are typically composed of a stable toxin and a labile antitoxin; the latter counteracts the toxicity of the former under suitable conditions. TA systems are classified into eight types based on the nature and molecular modes of action of the antitoxin component so far. The 10 pairs of TA systems discovered and experimentally characterised in Pseudomonas aeruginosa are type II TA systems. Type II TA systems have various physiological functions, such as virulence and biofilm formation, protection host against antibiotics, persistence, plasmid maintenance, and prophage production. Here, we review the type II TA systems of P. aeruginosa, focusing on their biological functions and regulatory mechanisms, providing potential applications for the novel drug design.
Keywords: Pseudomonas aeruginosa; type II; toxin–antitoxin system; biological function; regulatory mechanism Pseudomonas aeruginosa; type II; toxin–antitoxin system; biological function; regulatory mechanism

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MDPI and ACS Style

Li, M.; Guo, N.; Song, G.; Huang, Y.; Wang, L.; Zhang, Y.; Wang, T. Type II Toxin–Antitoxin Systems in Pseudomonas aeruginosa. Toxins 2023, 15, 164. https://doi.org/10.3390/toxins15020164

AMA Style

Li M, Guo N, Song G, Huang Y, Wang L, Zhang Y, Wang T. Type II Toxin–Antitoxin Systems in Pseudomonas aeruginosa. Toxins. 2023; 15(2):164. https://doi.org/10.3390/toxins15020164

Chicago/Turabian Style

Li, Meng, Nannan Guo, Gaoyu Song, Yi Huang, Lecheng Wang, Yani Zhang, and Tietao Wang. 2023. "Type II Toxin–Antitoxin Systems in Pseudomonas aeruginosa" Toxins 15, no. 2: 164. https://doi.org/10.3390/toxins15020164

APA Style

Li, M., Guo, N., Song, G., Huang, Y., Wang, L., Zhang, Y., & Wang, T. (2023). Type II Toxin–Antitoxin Systems in Pseudomonas aeruginosa. Toxins, 15(2), 164. https://doi.org/10.3390/toxins15020164

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